Literature DB >> 23063587

Phospholipase C-γ1 involved in brain disorders.

Hyun-Jun Jang1, Yong Ryoul Yang, Jung Kuk Kim, Jang Hyun Choi, Young-Kyo Seo, Yong Hwa Lee, Jeung Eun Lee, Sung Ho Ryu, Pann-Ghill Suh.   

Abstract

Phosphoinositide-specific phospholipase C-γ1 (PLC-γ1) is an important signaling regulator involved in various cellular processes. In brain, PLC-γ1 is highly expressed and participates in neuronal cell functions mediated by neurotrophins. Consistent with essential roles of PLC-γ1, it is involved in development of brain and synaptic transmission. Significantly, abnormal expression and activation of PLC-γ1 appears in various brain disorders such as epilepsy, depression, Huntington's disease and Alzheimer's disease. Thus, PLC-γ1 has been implicated in brain functions as well as related brain disorders. In this review, we discuss the roles of PLC-γ1 in neuronal functions and its pathological relevance to diverse brain diseases.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23063587     DOI： 10.1016/j.jbior.2012.09.008

Source DB:  PubMed          Journal:  Adv Biol Regul        ISSN： 2212-4926


  13 in total

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