Literature DB >> 23062712

The synthesis and antituberculosis activity of 5'-nor carbocyclic uracil derivatives.

Elena Matyugina1, Anastasia Khandazhinskaya, Larisa Chernousova, Sofia Andreevskaya, Tatiana Smirnova, Alexander Chizhov, Inna Karpenko, Sergey Kochetkov, Ludmila Alexandrova.   

Abstract

A series of new carbocyclic uracil derivatives were synthesized and evaluated as potential antituberculosis agents. Racemic 1-[4'-hydroxy-2'-cyclopenten-1'-yl]-5-tetradecynyluracil completely inhibited the growth of Mycobacterium tuberculosis H37Rv in vitro at a concentration of 10 μg/ml. Individual (+) and (-) isomers of the above uracil derivative were isolated and showed the same level of activity against two strains of Mycobacterium tuberculosis: laboratory sensitive (H37Rv) and clinical resistant to five top antituberculosis drugs (MS-115).
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23062712     DOI： 10.1016/j.bmc.2012.09.019

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  5 in total

1.  New Derivatives of 5-Substituted Uracils: Potential Agents with a Wide Spectrum of Biological Activity.

Authors:  Vasily A Kezin; Elena S Matyugina; Mikhail S Novikov; Alexander O Chizhov; Robert Snoeck; Graciela Andrei; Sergei N Kochetkov; Anastasia L Khandazhinskaya
Journal:  Molecules       Date:  2022-04-30       Impact factor: 4.927

2.  Evaluation of the Antiviral Potential of Modified Heterocyclic Base and 5'-Norcarbocyclic Nucleoside Analogs Against SARS-CoV-2.

Authors:  E S Matyugina; M S Novikov; L I Kozlovskaya; V P Volok; E Y Shustova; A A Ishmukhametov; S N Kochetkov; A L Khandazhinskaya
Journal:  Acta Naturae       Date:  2021 Oct-Dec       Impact factor: 1.845

Review 3.  Analogues of Pyrimidine Nucleosides as Mycobacteria Growth Inhibitors.

Authors:  Liudmila A Alexandrova; Anastasia L Khandazhinskaya; Elena S Matyugina; Dmitriy A Makarov; Sergey N Kochetkov
Journal:  Microorganisms       Date:  2022-06-27

4.  Novel 5'-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides.

Authors:  Anna A Klimenko; Elena S Matyugina; Evgeniya B Logashenko; Pavel N Solyev; Marina A Zenkova; Sergey N Kochetkov; Anastasia L Khandazhinskaya
Journal:  Molecules       Date:  2018-10-16       Impact factor: 4.411

5.  Investigation of 5'-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents.

Authors:  Anastasia L Khandazhinskaya; Elena S Matyugina; Pavel N Solyev; Maggie Wilkinson; Karen W Buckheit; Robert W Buckheit; Larisa N Chernousova; Tatiana G Smirnova; Sofya N Andreevskaya; Khalid J Alzahrani; Manal J Natto; Sergey N Kochetkov; Harry P de Koning; Katherine L Seley-Radtke
Journal:  Molecules       Date:  2019-09-21       Impact factor: 4.411
  5 in total

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