Literature DB >> 2306225

Intermediary metabolism in the Swarm rat chondrosarcoma chondrocyte.

C A Spencer1, T N Palmer, R M Mason.   

Abstract

The rat chondrosarcoma chondrocyte has the dual capacity to metabolize glucose (mainly via glycolysis) and glutamine (via an oxidative pathway). Glutamine metabolism, unlike that of glucose, is unable to sustain intracellular ATP concentrations. Glutamine consumption by the chondrosarcoma chondrocyte, however, is significantly in excess of its utilization as an amide-group donor in hexosamine synthesis, implying a novel and major role in cell metabolism.

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Year:  1990        PMID： 2306225      PMCID： PMC1133720          DOI： 10.1042/bj2650911

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  16 in total

1.  Metabolism of mucopolysaccharides in connective tissue. II. Synthesis of glucosamine-6-phosphate.

Authors:  A J BOLLET; A SHUSTER
Journal:  J Clin Invest       Date:  1960-07       Impact factor: 14.808

Review 2.  The role of high rates of glycolysis and glutamine utilization in rapidly dividing cells.

Authors:  E A Newsholme; B Crabtree; M S Ardawi
Journal:  Biosci Rep       Date:  1985-05       Impact factor: 3.840

3.  The interrelationship between glutamine and alanine in the intestine.

Authors:  P J Hanson; D S Parsons
Journal:  Biochem Soc Trans       Date:  1980-10       Impact factor: 5.407

4.  Biosynthesis of hyaluronic acid in cultures of chondrocytes from the Swarm rat chondrosarcoma.

Authors:  R M Mason; J H Kimura; V C Hascall
Journal:  J Biol Chem       Date:  1982-03-10       Impact factor: 5.157

5.  Biosynthesis of O-linked oligosaccharides on proteoglycans by chondrocytes from the swarm rat chondrosarcoma.

Authors:  E J Thonar; L S Lohmander; J H Kimura; S A Fellini; M Yanagishita; V C Hascall
Journal:  J Biol Chem       Date:  1983-10-10       Impact factor: 5.157

6.  Adrenergic inhibition of branched-chain 2-oxo acid dehydrogenase in rat diaphragm muscle in vitro.

Authors:  T N Palmer; M A Caldecourt; M C Sugden
Journal:  Biochem J       Date:  1983-10-15       Impact factor: 3.857

7.  Glutamine metabolism in lymphocytes of the rat.

Authors:  M S Ardawi; E A Newsholme
Journal:  Biochem J       Date:  1983-06-15       Impact factor: 3.857

8.  Biosynthesis of proteoglycans and their assembly into aggregates in cultures of chondrocytes from the Swarm rat chondrosarcoma.

Authors:  J H Kimura; T E Hardingham; V C Hascall; M Solursh
Journal:  J Biol Chem       Date:  1979-04-25       Impact factor: 5.157

9.  Microbiopsy metabolite and paired flow analysis: a new rapid procedure for homogenisation, extraction and analysis of high energy phosphates and other intermediates without any errors from tissue loss.

Authors:  D J Hearse
Journal:  Cardiovasc Res       Date:  1984-06       Impact factor: 10.787

10.  Ultrastructure of the chondrocytes and extracellular matrix of the swarm rat chondrosarcoma.

Authors:  G K Hascall
Journal:  Anat Rec       Date:  1980-10
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  8 in total

1.  Targeting mitochondrial responses to intra-articular fracture to prevent posttraumatic osteoarthritis.

Authors:  Mitchell C Coleman; Jessica E Goetz; Marc J Brouillette; Dongrim Seol; Michael C Willey; Emily B Petersen; Hope D Anderson; Nathan R Hendrickson; Jocelyn Compton; Behnoush Khorsand; Angie S Morris; Aliasger K Salem; Douglas C Fredericks; Todd O McKinley; James A Martin
Journal:  Sci Transl Med       Date:  2018-02-07       Impact factor: 17.956

2.  Elevated glutamine metabolism in splenocytes from spontaneously diabetic BB rats.

Authors:  G Y Wu; C J Field; E B Marliss
Journal:  Biochem J       Date:  1991-02-15       Impact factor: 3.857

3.  Evidence for a negative Pasteur effect in articular cartilage.

Authors:  R B Lee; J P Urban
Journal:  Biochem J       Date:  1997-01-01       Impact factor: 3.857

4.  Proteomic analysis profile of engineered articular cartilage with chondrogenic differentiated adipose tissue-derived stem cells loaded polyglycolic acid mesh for weight-bearing area defect repair.

Authors:  Lunli Gong; Xiao Zhou; Yaohao Wu; Yun Zhang; Chen Wang; Heng Zhou; Fangfang Guo; Lei Cui
Journal:  Tissue Eng Part A       Date:  2013-11-14       Impact factor: 3.845

5.  Chondrocyte-mediated catabolism of aggrecan: aggrecanase-dependent cleavage induced by interleukin-1 or retinoic acid can be inhibited by glucosamine.

Authors:  J D Sandy; D Gamett; V Thompson; C Verscharen
Journal:  Biochem J       Date:  1998-10-01       Impact factor: 3.857

6.  Serum factors, growth factors and UDP-sugar metabolism in bovine articular cartilage chondrocytes.

Authors:  G E Ysart; R M Mason
Journal:  Biochem J       Date:  1994-11-01       Impact factor: 3.857

7.  Preferential mRNA expression of prostromelysin relative to procollagenase and in situ localization in human articular cartilage.

Authors:  Q Nguyen; J S Mort; P J Roughley
Journal:  J Clin Invest       Date:  1992-04       Impact factor: 14.808

8.  Nitric oxide compounds have different effects profiles on human articular chondrocyte metabolism.

Authors:  María C de Andrés; Emilia Maneiro; Miguel A Martín; Joaquín Arenas; Francisco J Blanco
Journal:  Arthritis Res Ther       Date:  2013       Impact factor: 5.156
  8 in total

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