Literature DB >> 23061607

Organosilicon molecules with medicinal applications.

Annaliese K Franz1, Sean O Wilson.   

Abstract

The incorporation of silicon and synthesis of organosilicon small molecules provide unique opportunities for medicinal applications. The biological investigation of organosilicon small molecules is particularly interesting because of differences in their chemical properties that can contribute to enhanced potency and improved pharmacological attributes. Applications such as inhibitor design, imaging, drug release technology, and mapping inhibitor binding are discussed.

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Year:  2012        PMID: 23061607     DOI: 10.1021/jm3010114

Source DB:  PubMed          Journal:  J Med Chem        ISSN: 0022-2623            Impact factor:   7.446


  62 in total

1.  Why You Really Should Consider Using Palladium-Catalyzed Cross-Coupling of Silanols and Silanolates.

Authors:  Scott E Denmark; Andrea Ambrosi
Journal:  Org Process Res Dev       Date:  2015       Impact factor: 3.317

Review 2.  Catalysis in service of main group chemistry offers a versatile approach to p-block molecules and materials.

Authors:  Erin M Leitao; Titel Jurca; Ian Manners
Journal:  Nat Chem       Date:  2013-10       Impact factor: 24.427

3.  Mechanistic Investigation of Biocatalytic Heme Carbenoid Si-H Insertions.

Authors:  Rahul L Khade; Ajay L Chandgude; Rudi Fasan; Yong Zhang
Journal:  ChemCatChem       Date:  2019-05-08       Impact factor: 5.686

4.  Silanediol Anion Binding and Enantioselective Catalysis.

Authors:  Jonathan W Attard; Kohei Osawa; Yong Guan; Jessica Hatt; Shin-Ichi Kondo; Anita Mattson
Journal:  Synthesis (Stuttg)       Date:  2019-03-12       Impact factor: 3.157

5.  Enantioselective Borylation of Aromatic C-H Bonds with Chiral Dinitrogen Ligands.

Authors:  Bo Su; Tai-Gang Zhou; Pei-Lin Xu; Zhang-Jie Shi; John F Hartwig
Journal:  Angew Chem Int Ed Engl       Date:  2017-05-16       Impact factor: 15.336

6.  Catalytic C-H bond silylation of aromatic heterocycles.

Authors:  Anton A Toutov; Wen-Bo Liu; Kerry N Betz; Brian M Stoltz; Robert H Grubbs
Journal:  Nat Protoc       Date:  2015-10-29       Impact factor: 13.491

7.  Design and expeditious synthesis of organosilanes as potent antivirals targeting multidrug-resistant influenza A viruses.

Authors:  Yanmei Hu; Yuanxiang Wang; Fang Li; Chunlong Ma; Jun Wang
Journal:  Eur J Med Chem       Date:  2017-04-20       Impact factor: 6.514

8.  Iridium-Catalyzed, β-Selective C(sp3)-H Silylation of Aliphatic Amines To Form Silapyrrolidines and 1,2-Amino Alcohols.

Authors:  Bo Su; Taegyo Lee; John F Hartwig
Journal:  J Am Chem Soc       Date:  2018-12-13       Impact factor: 15.419

9.  Silicon Incorporated Morpholine Antifungals: Design, Synthesis, and Biological Evaluation.

Authors:  Gorakhnath R Jachak; Remya Ramesh; Duhita G Sant; Shweta U Jorwekar; Manjusha R Jadhav; Santosh G Tupe; Mukund V Deshpande; D Srinivasa Reddy
Journal:  ACS Med Chem Lett       Date:  2015-09-22       Impact factor: 4.345

10.  Design, Synthesis, and Identification of Silicon Incorporated Oxazolidinone Antibiotics with Improved Brain Exposure.

Authors:  B Seetharamsingh; Remya Ramesh; Santoshkumar S Dange; Pankaj V Khairnar; Smita Singhal; Dilip Upadhyay; Sridhar Veeraraghavan; Srikant Viswanadha; Swaroop Vakkalanka; D Srinivasa Reddy
Journal:  ACS Med Chem Lett       Date:  2015-10-26       Impact factor: 4.345

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