Literature DB >> 23061536

Chichibabin-type direct alkylation of pyridyl alcohols with alkyl lithium reagents.

Jenna L Jeffrey1, Richmond Sarpong.   

Abstract

Direct C(6) alkylation of pyridyl alcohols can be achieved following an initial deprotonation of the hydroxy group. This transformation, which is believed to occur by a Chichibabin-type alkylation, avoids lateral deprotonation prior to pyridine ring alkylation and gives increased regioselectivity for C(6) over C(4) alkylation.

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Year:  2012        PMID： 23061536      PMCID： PMC3503527          DOI： 10.1021/ol3024117

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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