Literature DB >> 23059633

Antiplasmodial and antibacterial activity of compounds isolated from Ormocarpum trichocarpum.

Jude C Chukwujekwu1, Carmen A de Kock, Peter J Smith, Fanie R van Heerden, Johannes van Staden.   

Abstract

Using activity-guided fractionation based on in vitro antibacterial assays, five biflavonoids, among them two new ones, were isolated from the aerial parts of Ormocarpum trichocarpum. The isolated compounds showed MIC values in the range of 4.0 to 136.7 µM against Staphylococcus aureus, Bacillus subtilis, Escherichia coli, and Klebsiella pneumonia and IC50 values in the range of 4.30 to 94.32 µM against the chloroquine-sensitive D10 Plasmodium falciparum strain. Georg Thieme Verlag KG Stuttgart · New York.

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Year:  2012        PMID： 23059633     DOI： 10.1055/s-0032-1315386

Source DB:  PubMed          Journal:  Planta Med        ISSN： 0032-0943            Impact factor:   3.352


  3 in total

Review 1.  Ethnobotany and the Role of Plant Natural Products in Antibiotic Drug Discovery.

Authors:  Gina Porras; François Chassagne; James T Lyles; Lewis Marquez; Micah Dettweiler; Akram M Salam; Tharanga Samarakoon; Sarah Shabih; Darya Raschid Farrokhi; Cassandra L Quave
Journal:  Chem Rev       Date:  2020-11-09       Impact factor: 60.622

2.  Biflavanones, Chalconoids, and Flavonoid Analogues from the Stem Bark of Ochna holstii.

Authors:  Thobias M Kalenga; Monica M Ndoile; Yoseph Atilaw; Pieter J Gilissen; Joan J E Munissi; Anastasia Rudenko; Catarina Bourgard; Per Sunnerhagen; Stephen S Nyandoro; Mate Erdelyi
Journal:  J Nat Prod       Date:  2021-01-29       Impact factor: 4.050

3.  Total synthesis of ochnaflavone.

Authors:  Monica M Ndoile; Fanie R van Heerden
Journal:  Beilstein J Org Chem       Date:  2013-07-08       Impact factor: 2.883
  3 in total

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