Ying-Yong Zhao1, Ya-Long Feng, Xiao Du, Zhi-Hui Xi, Xian-Long Cheng, Feng Wei. 1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, College of Life Sciences, Northwest University, No. 229 Taibai North Road, Xi'an, Shaanxi 710069, PR China. zyy@nwu.edu.cn
Abstract
ETHNOPHARMACOLOGICAL RELEVANCE: Poria cocos Wolf (Polyporaceae) is a well-known traditional East-Asian medicinal fungus. the epidermis ("Fu-Ling-Pi" in Chinese) of the sclerotia is used as a diuretic. This study was conducted to evaluate of ethanol extract (EE) and aqueous extract (AE) of the diuretic activity of Fu-Ling-Pi in saline-loaded rats. MATERIAL AND METHODS: The EE and AE were orally administered to rats. Urinary excretion rate, pH and electrolyte excretion were measured in the urine of saline-loaded rats. RESULTS: Urinary excretion rates were significantly increased by the EE. The three doses of AE only produced a slight increase urinary output. The EE had little or no effect on K(+) excretion, but did indeed induce a notable excretion of Na(+), that was in agreement with the urinary excretion. The three doses of AE produced an increase Na(+) and K(+) excretion, but did not arrive at statistical significance. CONCLUSIONS: The present study confirmed that the not aqueous but ethanol extracts of the epidermis of Poria cocos presents a remarkable diuretic effect.
ETHNOPHARMACOLOGICAL RELEVANCE: Poria cocos Wolf (Polyporaceae) is a well-known traditional East-Asian medicinal fungus. the epidermis ("Fu-Ling-Pi" in Chinese) of the sclerotia is used as a diuretic. This study was conducted to evaluate of ethanol extract (EE) and aqueous extract (AE) of the diuretic activity of Fu-Ling-Pi in saline-loaded rats. MATERIAL AND METHODS: The EE and AE were orally administered to rats. Urinary excretion rate, pH and electrolyte excretion were measured in the urine of saline-loaded rats. RESULTS: Urinary excretion rates were significantly increased by the EE. The three doses of AE only produced a slight increase urinary output. The EE had little or no effect on K(+) excretion, but did indeed induce a notable excretion of Na(+), that was in agreement with the urinary excretion. The three doses of AE produced an increase Na(+) and K(+) excretion, but did not arrive at statistical significance. CONCLUSIONS: The present study confirmed that the not aqueous but ethanol extracts of the epidermis of Poria cocos presents a remarkable diuretic effect.
Authors: Ya-Long Feng; Gang Cao; Dan-Qian Chen; Nosratola D Vaziri; Lin Chen; Jun Zhang; Ming Wang; Yan Guo; Ying-Yong Zhao Journal: Cell Mol Life Sci Date: 2019-05-30 Impact factor: 9.261
Authors: Ming Wang; Dan-Qian Chen; Lin Chen; Gang Cao; Hui Zhao; Dan Liu; Nosratola D Vaziri; Yan Guo; Ying-Yong Zhao Journal: Br J Pharmacol Date: 2018-05-22 Impact factor: 8.739
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