| Literature DB >> 23058853 |
Jason H Anderson1, Johan Martijn Bos, Fredric B Meyer, Gregory D Cascino, Michael J Ackerman.
Abstract
Herein, we describe a patient with concealed type 2 long QT syndrome with concomitant electroencephalogram-documented epilepsy. Although syncope in patients with long QT syndrome is common and often secondary to cerebral hypoxia after a protracted ventricular arrhythmia, this article demonstrates the importance of avoiding "tunnel vision" as patients with long QT syndrome could also have a primary seizure disorder. Identification of the etiology underlying seizurelike activity is paramount in instituting effective therapy. Furthermore, we theorize that abnormal KCHN2-encoded potassium channel repolarization in the brain could result in epilepsy and arrhythmias in long QT syndrome.Entities:
Mesh:
Year: 2012 PMID: 23058853 PMCID: PMC3532686 DOI: 10.1016/j.mayocp.2012.07.019
Source DB: PubMed Journal: Mayo Clin Proc ISSN: 0025-6196 Impact factor: 7.616