Literature DB >> 23058853

Concealed long QT syndrome and intractable partial epilepsy: a case report.

Jason H Anderson1, Johan Martijn Bos, Fredric B Meyer, Gregory D Cascino, Michael J Ackerman.   

Abstract

Herein, we describe a patient with concealed type 2 long QT syndrome with concomitant electroencephalogram-documented epilepsy. Although syncope in patients with long QT syndrome is common and often secondary to cerebral hypoxia after a protracted ventricular arrhythmia, this article demonstrates the importance of avoiding "tunnel vision" as patients with long QT syndrome could also have a primary seizure disorder. Identification of the etiology underlying seizurelike activity is paramount in instituting effective therapy. Furthermore, we theorize that abnormal KCHN2-encoded potassium channel repolarization in the brain could result in epilepsy and arrhythmias in long QT syndrome.
Copyright © 2012 Mayo Foundation for Medical Education and Research. Published by Elsevier Inc. All rights reserved.

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Year:  2012        PMID: 23058853      PMCID: PMC3532686          DOI: 10.1016/j.mayocp.2012.07.019

Source DB:  PubMed          Journal:  Mayo Clin Proc        ISSN: 0025-6196            Impact factor:   7.616


  16 in total

1.  Congenital deaf-mutism, functional heart disease with prolongation of the Q-T interval and sudden death.

Authors:  A JERVELL; F LANGE-NIELSEN
Journal:  Am Heart J       Date:  1957-07       Impact factor: 4.749

Review 2.  ACC/AHA/HRS 2008 guidelines for Device-Based Therapy of Cardiac Rhythm Abnormalities: executive summary.

Authors:  Andrew E Epstein; John P Dimarco; Kenneth A Ellenbogen; N A Mark Estes; Roger A Freedman; Leonard S Gettes; A Marc Gillinov; Gabriel Gregoratos; Stephen C Hammill; David L Hayes; Mark A Hlatky; L Kristin Newby; Richard L Page; Mark H Schoenfeld; Michael J Silka; Lynne Warner Stevenson; Michael O Sweeney
Journal:  Heart Rhythm       Date:  2008-05-19       Impact factor: 6.343

3.  Reduction of K+ uptake in glia prevents long-term depression maintenance and causes epileptiform activity.

Authors:  D Janigro; S Gasparini; R D'Ambrosio; G McKhann; D DiFrancesco
Journal:  J Neurosci       Date:  1997-04-15       Impact factor: 6.167

4.  A family of potassium channel genes related to eag in Drosophila and mammals.

Authors:  J W Warmke; B Ganetzky
Journal:  Proc Natl Acad Sci U S A       Date:  1994-04-12       Impact factor: 11.205

Review 5.  The inherited long QT syndrome: from ion channel to bedside.

Authors:  G M Vincent; K Timothy; J Fox; L Zhang
Journal:  Cardiol Rev       Date:  1999 Jan-Feb       Impact factor: 2.644

Review 6.  The long QT syndrome: ion channel diseases of the heart.

Authors:  M J Ackerman
Journal:  Mayo Clin Proc       Date:  1998-03       Impact factor: 7.616

7.  Impaired K(+) homeostasis and altered electrophysiological properties of post-traumatic hippocampal glia.

Authors:  R D'Ambrosio; D O Maris; M S Grady; H R Winn; D Janigro
Journal:  J Neurosci       Date:  1999-09-15       Impact factor: 6.167

8.  A novel mutation in the potassium channel gene KVLQT1 causes the Jervell and Lange-Nielsen cardioauditory syndrome.

Authors:  N Neyroud; F Tesson; I Denjoy; M Leibovici; C Donger; J Barhanin; S Fauré; F Gary; P Coumel; C Petit; K Schwartz; P Guicheney
Journal:  Nat Genet       Date:  1997-02       Impact factor: 38.330

9.  Syncope--brain or heart? A case report.

Authors:  H Nilsson; M Freitag; B Hindfelt; B W Johansson; I Rosén
Journal:  Pacing Clin Electrophysiol       Date:  1992-06       Impact factor: 1.976

10.  Implantable cardioverter defibrillator in high-risk long QT syndrome patients.

Authors:  Wojciech Zareba; Arthur J Moss; James P Daubert; W Jackson Hall; Jennifer L Robinson; Mark Andrews
Journal:  J Cardiovasc Electrophysiol       Date:  2003-04
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  5 in total

1.  Importance of cardiological evaluation for first seizures.

Authors:  Ho Choong; Ibrahim Hanna; Roy Beran
Journal:  World J Clin Cases       Date:  2015-04-16       Impact factor: 1.337

Review 2.  The ERG1 K+ Channel and Its Role in Neuronal Health and Disease.

Authors:  Francisco G Sanchez-Conde; Eric N Jimenez-Vazquez; David S Auerbach; David K Jones
Journal:  Front Mol Neurosci       Date:  2022-05-03       Impact factor: 6.261

3.  Genetic and forensic implications in epilepsy and cardiac arrhythmias: a case series.

Authors:  Sara Partemi; Monica Coll Vidal; Pasquale Striano; Oscar Campuzano; Catarina Allegue; Marianna Pezzella; Maurizio Elia; Pasquale Parisi; Vincenzo Belcastro; Susanna Casellato; Lucio Giordano; Massimo Mastrangelo; Nicola Pietrafusa; Salvatore Striano; Federico Zara; Amedeo Bianchi; Daniela Buti; Angela La Neve; Carlo Alberto Tassinari; Antonio Oliva; Ramon Brugada
Journal:  Int J Legal Med       Date:  2014-08-15       Impact factor: 2.686

4.  Confirmation of Cause of Death Via Comprehensive Autopsy and Whole Exome Molecular Sequencing in People With Epilepsy and Sudden Unexpected Death.

Authors:  C Anwar A Chahal; David J Tester; Ahmed U Fayyaz; Keerthi Jaliparthy; Nadeem A Khan; Dongmei Lu; Mariha Khan; Aradhana Sahoo; Aiswarya Rajendran; Jennifer A Knight; Michael A Simpson; Elijah R Behr; Elson L So; Erik K St Louis; R Ross Reichard; William D Edwards; Michael J Ackerman; Virend K Somers
Journal:  J Am Heart Assoc       Date:  2021-11-24       Impact factor: 6.106

5.  Systematic Review of the Genetics of Sudden Unexpected Death in Epilepsy: Potential Overlap With Sudden Cardiac Death and Arrhythmia-Related Genes.

Authors:  C Anwar A Chahal; Mohammad N Salloum; Fares Alahdab; Joseph A Gottwald; David J Tester; Lucman A Anwer; Elson L So; Mohammad Hassan Murad; Erik K St Louis; Michael J Ackerman; Virend K Somers
Journal:  J Am Heart Assoc       Date:  2019-12-21       Impact factor: 5.501

  5 in total

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