Literature DB >> 23057671

Azepane quaternary amino acids as effective inducers of 3(10) helix conformations.

Diego Núñez-Villanueva1, Lourdes Infantes, M Teresa García-López, Rosario González-Muñiz, Mercedes Martín-Martínez.   

Abstract

A simple method for the synthesis of an azepane quaternary amino acid in enantiopure form is described. Theoretical, NMR, and X-ray studies indicated that this azepane-derived amino acid is an effective stabilizer of 3(10) helical structures in short peptides.

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Year:  2012        PMID： 23057671     DOI： 10.1021/jo301379r

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  2 in total

1.  Synthesis and Deployment of an Elusive Fluorovinyl Cation Equivalent: Access to Quaternary α-(1'-Fluoro)vinyl Amino Acids as Potential PLP Enzyme Inactivators.

Authors:  Christopher D McCune; Matthew L Beio; Jill M Sturdivant; Roberto de la Salud-Bea; Brendan M Darnell; David B Berkowitz
Journal:  J Am Chem Soc       Date:  2017-09-28       Impact factor: 15.419

2.  Synthesis of Substituted Oxo-Azepines by Regio- and Diastereoselective Hydroxylation.

Authors:  Harold Spedding; Peter Karuso; Fei Liu
Journal:  Molecules       Date:  2017-10-31       Impact factor: 4.411
  2 in total

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