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Literature DB >> 23054915

Chronic stress elevates telomerase activity in rats.

Annaliese K Beery¹, Jue Lin, Joshua S Biddle, Darlene D Francis, Elizabeth H Blackburn, Elissa S Epel.

Abstract

The enzyme telomerase lengthens telomeres-protective structures containing repetitive DNA sequences at chromosome ends. Telomere shortening is associated with diseases of ageing in mammals. Chronic stress has been related to shorter immune-cell telomeres, but telomerase activity under stress may be low, permitting telomere loss, or high, partially attenuating it. We developed an experimental model to examine the impacts of extended unpredictable stress on telomerase activity in male rats. Telomerase activity was 54 per cent higher in stressed rats than in controls, and associated with stress-related physiological and behavioural outcomes. This significant increase suggests a potential mechanism for resilience to stress-related replicative senescence.

Entities: Species

Mesh：

Substances：
Telomerase
Corticosterone

Year: 2012 PMID： 23054915 PMCID： PMC3497144 DOI： 10.1098/rsbl.2012.0747

Source DB: PubMed Journal: Biol Lett ISSN： 1744-9561 Impact factor: 3.703

29 in total

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Review 2. In vivo regulation of telomerase activity and telomere length.

Authors: Karen S Hathcock; Y Jeffrey Chiang; Richard J Hodes
Journal: Immunol Rev Date: 2005-06 Impact factor: 12.988

3. Changes in some parameters of the immune response in rats after cold stress.

Authors: D Goundasheva; M Andonova; V Ivanov
Journal: Zentralbl Veterinarmed B Date: 1994-12

4. Effects of acute and chronic social stress on blood cellular immunity in rats.

Authors: V Stefanski; H Engler
Journal: Physiol Behav Date: 1998-07

5. Telomerase activity in rat cardiac myocytes is age and gender dependent.

Authors: A Leri; A Malhotra; C C Liew; J Kajstura; P Anversa
Journal: J Mol Cell Cardiol Date: 2000-03 Impact factor: 5.000

6. Chronic restraint attenuates the immunosuppressive response induced by novel aversive stimuli.

Authors: A M Basso; M Depiante-Depaoli; L Cancela; V A Molina
Journal: Physiol Behav Date: 1994-06

7. The use of the elevated plus maze as an assay of anxiety-related behavior in rodents.

Authors: Alicia A Walf; Cheryl A Frye
Journal: Nat Protoc Date: 2007 Impact factor: 13.491

Review 8. Telomerase and cancer stem cells.

Authors: M Armanios; C W Greider
Journal: Cold Spring Harb Symp Quant Biol Date: 2005

9. Accelerated telomere shortening in response to life stress.

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Journal: Proc Natl Acad Sci U S A Date: 2004-12-01 Impact factor: 11.205

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Authors: Daniel Lindqvist; Elissa S Epel; Synthia H Mellon; Brenda W Penninx; Dóra Révész; Josine E Verhoeven; Victor I Reus; Jue Lin; Laura Mahan; Christina M Hough; Rebecca Rosser; F Saverio Bersani; Elizabeth H Blackburn; Owen M Wolkowitz
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3. Relationship between leukocyte telomere length, telomerase activity, and hippocampal volume in early aging.

Authors: Emily G Jacobs; Elissa S Epel; Jue Lin; Elizabeth H Blackburn; Natalie L Rasgon
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4. Association between informal caregiving and cellular aging in the survey of the health of wisconsin: the role of caregiving characteristics, stress, and strain.

Authors: Kristin Litzelman; Whitney P Witt; Ronald E Gangnon; F Javier Nieto; Corinne D Engelman; Marsha R Mailick; Halcyon G Skinner
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5. Cellular response to chronic psychosocial stress: Ten-year longitudinal changes in telomere length in the Multi-Ethnic Study of Atherosclerosis.

Authors: Helen C S Meier; Mustafa Hussein; Belinda Needham; Sharrelle Barber; Jue Lin; Teresa Seeman; Ana Diez Roux
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Review 6. Do Hormones, Telomere Lengths, and Oxidative Stress form an Integrated Phenotype? A Case Study in Free-Living Tree Swallows.

Authors: J Q Ouyang; Á Z Lendvai; I T Moore; F Bonier; M F Haussmann
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7. Moderate-to-severe obstructive sleep apnea is associated with telomere lengthening.

Authors: Katarzyna Polonis; Virend K Somers; Christiane Becari; Naima Covassin; Phillip J Schulte; Brooke R Druliner; Ruth A Johnson; Krzysztof Narkiewicz; Lisa A Boardman; Prachi Singh
Journal: Am J Physiol Heart Circ Physiol Date: 2017-08-19 Impact factor: 4.733