| Literature DB >> 23054412 |
Amedeo Amedei1, Fabio Munari, Chiara Della Bella, Elena Niccolai, Marisa Benagiano, Lapo Bencini, Fabio Cianchi, Marco Farsi, Giacomo Emmi, Giuseppe Zanotti, Marina de Bernard, Manikuntala Kundu, Mario Milco D'Elios.
Abstract
Helicobacter pylori infection is characterized by an inflammatory infiltrate, consisting mainly of neutrophils and T cells. This study was undertaken to evaluate the type of gastric T cell response elicited by the secreted peptidyl prolyl cis, trans-isomerase of H. pylori (HP0175) in patients with distal gastric adenocarcinoma. The cytokine profile and the effector functions of gastric tumor-infiltrating lymphocytes (TILs) specific for HP0175 was investigated in 20 patients with distal gastric adenocarcinoma and H. pylori infection. The helper function of HP0175-specific TILs for monocyte MMP-2, MMP-9, and VEGF production was also investigated. TILs cells from H. pylori infected patients with distal gastric adenocarcinoma produced Interleukin (IL)-17 and IL-21 in response to HP0175. HP0175-specific TILs showed poor cytolytic activity while expressing helper activity for monocyte MMP-2, MMP-9 and VEGF production. These findings indicate that HP0175 is able to drive gastric Th17 response. Thus, HP0175, by promoting pro-inflammatory low cytotoxic TIL response, matrix degradation and pro-angiogenic pathways, may provide a link between H. pylori and gastric cancer.Entities:
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Year: 2012 PMID： 23054412 DOI： 10.1007/s11739-012-0867-9
Source DB: PubMed Journal: Intern Emerg Med ISSN： 1828-0447 Impact factor: 3.397