Literature DB >> 230543

II - Prostaglandin hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists.

S H Ferreira, M Nakamura.   

Abstract

Morphine, enkephalins, nalorphine, naloxone and pentazocine are shown to have a peripheral analgesic effect. In our modification of the Randall-Selitto test these substances were 50--100 times more potent than a standard local anaesthetic, lidocaine. At this peripheral site, naloxone did not antagonize the effect of morphine. Morphine had a marked analgesic effect on the hyperalgesia induced by PGE2 and PGI2, BaCl2, Ca2+ ionophore A23187, isoprenaline but not on that induced by dibutyryl cyclic AMP. It was suggested that the peripheral analgesic effect of morphine is due to an inhibition of adenylate-cyclase activity.

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Year:  1979        PMID： 230543     DOI： 10.1016/0090-6980(79)90104-7

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  48 in total

1.  Allosteric interactions between δ and κ opioid receptors in peripheral sensory neurons.

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2.  A preliminary study of the pharmacodynamics and pharmacokinetics of a novel enkephalin analogue [Tyr-D.Arg-Gly-Phe (4NO2).Pro.NH2 (BW443C)] in healthy volunteers.

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3.  Profile of Sérgio Ferreira.

Authors:  Philip Downey
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4.  Postoperative analgesic effects of an external cooling system and intra-articular bupivacaine/morphine after arthroscopic cruciate ligament surgery.

Authors:  S Brandsson; B Rydgren; T Hedner; B I Eriksson; O Lundin; L Swärd; J Karlsson
Journal:  Knee Surg Sports Traumatol Arthrosc       Date:  1996       Impact factor: 4.342

5.  Teleantagonism: A pharmacodynamic property of the primary nociceptive neuron.

Authors:  Mani I Funez; Luiz F Ferrari; Djane B Duarte; Daniela Sachs; Fernando Q Cunha; Berenice B Lorenzetti; Carlos A Parada; Sérgio H Ferreira
Journal:  Proc Natl Acad Sci U S A       Date:  2008-09-17       Impact factor: 11.205

6.  [Peripheral opioid receptors and their role in postoperative pain management.].

Authors:  C Stein
Journal:  Schmerz       Date:  1993-03       Impact factor: 1.107

7.  Opioids from immunocytes interact with receptors on sensory nerves to inhibit nociception in inflammation.

Authors:  C Stein; A H Hassan; R Przewłocki; C Gramsch; K Peter; A Herz
Journal:  Proc Natl Acad Sci U S A       Date:  1990-08       Impact factor: 11.205

8.  Use of Positron Emission Tomography to Measure Brain Activity Responses to Fentanyl Analgesia.

Authors: 
Journal:  Curr Rev Pain       Date:  1999

9.  Opiate-induced inhibition of the visceral distension reflex by peripheral and central mechanisms.

Authors:  S J Clark; T W Smith
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1985-09       Impact factor: 3.000

Review 10.  The role of interleukins and nitric oxide in the mediation of inflammatory pain and its control by peripheral analgesics.

Authors:  S H Ferreira
Journal:  Drugs       Date:  1993       Impact factor: 9.546
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