Literature DB >> 230542

I - Prostaglandin hyperalgesia, a cAMP/Ca2+ dependent process.

S H Ferreira, M Nakamura.   

Abstract

Prostaglandins stimulate cAMP increase in several biological systems including CNS. The possible participation of a cAMP/Ca2+ related mechanism in prostaglandin induced hyperalgesia in the rat paw, as measured by a modification of the Randall-Selitto method was investigated. A serie of agents was administered in the paw in an attempt to change either Ca2+ or cyclic AMP concentration at the nociceptive terminations. PGE2, dibutyryl cyclic AMP, isoprenaline, noradrenaline, adrenaline, Ca2+ionophore (A23187), BaCl2 caused a dose dependent hyperalgesia. The hyperalgesic effect of these substances was enhanced by methyl-xanthines. Cyclic GMP as well as agents which interfere with Ca2+ influx (verapamil and lanthanum) were local analgesics in normal and hyperalgesic paws.

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Year:  1979        PMID： 230542     DOI： 10.1016/0090-6980(79)90103-5

Source DB:  PubMed          Journal:  Prostaglandins        ISSN： 0090-6980


  53 in total

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5.  Role of the haeme oxygenase/carbon monoxide pathway in mechanical nociceptor hypersensitivity.

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Review 8.  The role of interleukins and nitric oxide in the mediation of inflammatory pain and its control by peripheral analgesics.

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Review 9.  Peripheral analgesia: mechanism of the analgesic action of aspirin-like drugs and opiate-antagonists.

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