Literature DB >> 23053990

Protective roles of quercetin in acute myocardial ischemia and reperfusion injury in rats.

Hong-Bo Jin1, Yong-Bin Yang, Ying-Li Song, Yong-chun Zhang, Yu-Rong Li.   

Abstract

Myocardial ischemia and reperfusion (MI/R) is associated with an intense inflammatory reaction, which may lead to myocyte injury. In this study, we investigated the effect of quercetin, an inhibitor of c-Jun N-terminal kinase on ischemia/reperfusion injury in isolated rat hearts. Rat models of MI/R were induced by coronary occlusion followed by reperfusion, treatment of rats with quercetin (1.0 mg/kg, i.v.) induced a significant reduction of infarct volume and improvements in baseline hemodynamic abnormalities (P < 0.05). Quercetin treatment also attenuated the expression of both TNF-alpha (TNF-α) and interleukin-10 (IL-10) and lowered the serum levels of inflammatory cytokine (P < 0.05). These findings suggested that quercetin treatment significantly attenuated MI/R injury primarily through anti-inflammatory effects.

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Year:  2012        PMID： 23053990     DOI： 10.1007/s11033-012-2002-4

Source DB:  PubMed          Journal:  Mol Biol Rep        ISSN： 0301-4851            Impact factor:   2.316


  12 in total

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2.  Protection against myocardial ischaemia/reperfusion injury by PPAR-alpha activation is related to production of nitric oxide and endothelin-1.

Authors:  A A Bulhak; P-O Sjöquist; C-B Xu; L Edvinsson; J Pernow
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4.  Zinc pyrithione salvages reperfusion injury by inhibiting NADPH oxidase activation in cardiomyocytes.

Authors:  Viswanath Kasi; Sreedhar Bodiga; Upendra Nadh Kommuguri; Suneetha Sankuru; Vijaya Lakshmi Bodiga
Journal:  Biochem Biophys Res Commun       Date:  2011-05-27       Impact factor: 3.575

5.  Differential gene expression in coronary arteries from patients presenting with ischemic heart disease: further evidence for the inflammatory basis of atherosclerosis.

Authors:  Gemma Satterthwaite; Sheila E Francis; Kim Suvarna; Stephen Blakemore; Chantelle Ward; Don Wallace; Martin Braddock; David Crossman
Journal:  Am Heart J       Date:  2005-09       Impact factor: 4.749

6.  The effect of interleukin-10 knock-out and overexpression on neointima formation in hypercholesterolemic APOE*3-Leiden mice.

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7.  Early phase acute myocardial infarct size quantification: validation of the triphenyl tetrazolium chloride tissue enzyme staining technique.

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8.  Direct vascular and cardioprotective effects of rosuvastatin, a new HMG-CoA reductase inhibitor.

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Authors:  K Kaur; A K Sharma; P K Singal
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  16 in total

1.  The therapeutic effects of anti-oxidant and anti-inflammatory drug quercetin on aspiration-induced lung injury in rats.

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2.  Peroxisome proliferator-activated receptor γ (PPARγ) mediates the protective effect of quercetin against myocardial ischemia-reperfusion injury via suppressing the NF-κB pathway.

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Journal:  Am J Transl Res       Date:  2016-12-15       Impact factor: 4.060

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Journal:  Mol Cell Biochem       Date:  2018-01-10       Impact factor: 3.396

4.  The effects of quercetin protect cardiomyocytes from A/R injury is related to its capability to increasing expression and activity of PKCε protein.

Authors:  Lei Tang; Yian Peng; Tiantian Xu; Xiaoqing Yi; Ying Liu; Yuchao Luo; Dong Yin; Ming He
Journal:  Mol Cell Biochem       Date:  2013-06-23       Impact factor: 3.396

5.  Effects of Quercetin on Cardiac Function in Pressure Overload and Postischemic Cardiac Injury in Rodents: a Systematic Review and Meta-Analysis.

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6.  Phytochemical quercetin alleviates hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia comparable to NSAIDs.

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7.  Incretin attenuates diabetes-induced damage in rat cardiac tissue.

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Review 8.  Therapeutic potential of IKK-β inhibitors from natural phenolics for inflammation in cardiovascular diseases.

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Journal:  Inflammopharmacology       Date:  2020-01-01       Impact factor: 4.473

9.  Quercetin improves postischemic recovery of heart function in doxorubicin-treated rats and prevents doxorubicin-induced matrix metalloproteinase-2 activation and apoptosis induction.

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Journal:  Int J Mol Sci       Date:  2015-04-13       Impact factor: 5.923

10.  Cardioprotective Effect of Quercetin against Ischemia/Reperfusion Injury Is Mediated Through NO System and Mitochondrial K-ATP Channels.

Authors:  Ying Liu; Yi Song; Siyuan Li; Li Mo
Journal:  Cell J       Date:  2021-05-26       Impact factor: 2.479
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