OBJECTIVE: To determine whether anti-Müllerian hormone (AMH) production resumes during normal late menopausal aging. Anti-Müllerian hormone has been proposed as a specific serum marker for adult granulosa cell tumors. MATERIALS AND METHODS: Serum AMH from 21 elderly postmenopausal women (mean age, 77 years) and 9 young women (mean age, 22 years) were measured by ultrasensitive immunoassay. RESULTS: Both median (0 pmol/L) and mean (0.48 pmol/L) serum AMH values for the elderly women were below the level of detection for the immunoassay kit. Three of the 21 participants had minimally detectable level of AMH (1.13-2.76 pmol/L). The cohort of young women had expected normal values of AMH as measurable by the same immunoassay kit. CONCLUSIONS: Serum AMH values were negligible for postmenopausal women older than 65 years. This extends the normative data for AMH to 108 years old, providing a reference range for the detection of granulosa cell tumors in postmenopausal women.
OBJECTIVE: To determine whether anti-Müllerian hormone (AMH) production resumes during normal late menopausal aging. Anti-Müllerian hormone has been proposed as a specific serum marker for adult granulosa cell tumors. MATERIALS AND METHODS: Serum AMH from 21 elderly postmenopausal women (mean age, 77 years) and 9 young women (mean age, 22 years) were measured by ultrasensitive immunoassay. RESULTS: Both median (0 pmol/L) and mean (0.48 pmol/L) serum AMH values for the elderly women were below the level of detection for the immunoassay kit. Three of the 21 participants had minimally detectable level of AMH (1.13-2.76 pmol/L). The cohort of young women had expected normal values of AMH as measurable by the same immunoassay kit. CONCLUSIONS: Serum AMH values were negligible for postmenopausal women older than 65 years. This extends the normative data for AMH to 108 years old, providing a reference range for the detection of granulosa cell tumors in postmenopausal women.
Authors: K A Kissell; M R Danaher; E F Schisterman; J Wactawski-Wende; K A Ahrens; K Schliep; N J Perkins; L Sjaarda; J Weck; S L Mumford Journal: Hum Reprod Date: 2014-06-12 Impact factor: 6.918
Authors: Hang Wun Raymond Li; David Mark Robertson; Chris Burns; William Leigh Ledger Journal: Front Endocrinol (Lausanne) Date: 2021-05-24 Impact factor: 5.555
Authors: Yih Harng Chong; Nicola A Dennis; Martin J Connolly; Ruth Teh; Gregory T Jones; Andre M van Rij; Stephanie Farrand; A John Campbell; Ian S McLennan; Ian S Mlennan Journal: PLoS One Date: 2013-08-05 Impact factor: 3.240