Literature DB >> 23051805

Assessing unintended hybridization-induced biological effects of oligonucleotides.

Morten Lindow, Hans-Peter Vornlocher, Donald Riley, Douglas J Kornbrust, Julja Burchard, Laurence O Whiteley, Joanne Kamens, James D Thompson, Saraswathy Nochur, Husam Younis, Steven Bartz, Joel Parry, Nicolay Ferrari, Scott P Henry, Arthur A Levin.   

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Year:  2012        PMID： 23051805     DOI： 10.1038/nbt.2376

Source DB:  PubMed          Journal:  Nat Biotechnol        ISSN： 1087-0156            Impact factor:   54.908


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  10 in total

1.  Phosphorothioate oligonucleotides inhibit the intrinsic tenase complex by an allosteric mechanism.

Authors:  J P Sheehan; T M Phan
Journal:  Biochemistry       Date:  2001-04-24       Impact factor: 3.162

2.  Expression profiling reveals off-target gene regulation by RNAi.

Authors:  Aimee L Jackson; Steven R Bartz; Janell Schelter; Sumire V Kobayashi; Julja Burchard; Mao Mao; Bin Li; Guy Cavet; Peter S Linsley
Journal:  Nat Biotechnol       Date:  2003-05-18       Impact factor: 54.908

3.  Many commonly used siRNAs risk off-target activity.

Authors:  Ola Snøve; Torgeir Holen
Journal:  Biochem Biophys Res Commun       Date:  2004-06-18       Impact factor: 3.575

4.  Widespread siRNA "off-target" transcript silencing mediated by seed region sequence complementarity.

Authors:  Aimee L Jackson; Julja Burchard; Janell Schelter; B Nelson Chau; Michele Cleary; Lee Lim; Peter S Linsley
Journal:  RNA       Date:  2006-05-08       Impact factor: 4.942

Review 5.  RNA targeting therapeutics: molecular mechanisms of antisense oligonucleotides as a therapeutic platform.

Authors:  C Frank Bennett; Eric E Swayze
Journal:  Annu Rev Pharmacol Toxicol       Date:  2010       Impact factor: 13.820

6.  Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.

Authors:  A Fire; S Xu; M K Montgomery; S A Kostas; S E Driver; C C Mello
Journal:  Nature       Date:  1998-02-19       Impact factor: 49.962

7.  Inhibition of Rous sarcoma virus replication and cell transformation by a specific oligodeoxynucleotide.

Authors:  P C Zamecnik; M L Stephenson
Journal:  Proc Natl Acad Sci U S A       Date:  1978-01       Impact factor: 11.205

8.  Silencing of microRNA families by seed-targeting tiny LNAs.

Authors:  Susanna Obad; Camila O dos Santos; Andreas Petri; Markus Heidenblad; Oliver Broom; Cristian Ruse; Cexiong Fu; Morten Lindow; Jan Stenvang; Ellen Marie Straarup; Henrik Frydenlund Hansen; Troels Koch; Darryl Pappin; Gregory J Hannon; Sakari Kauppinen
Journal:  Nat Genet       Date:  2011-03-20       Impact factor: 38.330

9.  MicroRNA-like off-target transcript regulation by siRNAs is species specific.

Authors:  Julja Burchard; Aimee L Jackson; Vladislav Malkov; Rachel H V Needham; Yejun Tan; Steven R Bartz; Hongyue Dai; Alan B Sachs; Peter S Linsley
Journal:  RNA       Date:  2009-02       Impact factor: 4.942

10.  Designing siRNA that distinguish between genes that differ by a single nucleotide.

Authors:  Dianne S Schwarz; Hongliu Ding; Lori Kennington; Jessica T Moore; Janell Schelter; Julja Burchard; Peter S Linsley; Neil Aronin; Zuoshang Xu; Phillip D Zamore
Journal:  PLoS Genet       Date:  2006-07-24       Impact factor: 5.917
  10 in total
  31 in total

Review 1.  Managing the sequence-specificity of antisense oligonucleotides in drug discovery.

Authors:  Peter H Hagedorn; Bo R Hansen; Troels Koch; Morten Lindow
Journal:  Nucleic Acids Res       Date:  2017-03-17       Impact factor: 16.971

2.  RNase H sequence preferences influence antisense oligonucleotide efficiency.

Authors:  Lukasz J Kielpinski; Peter H Hagedorn; Morten Lindow; Jeppe Vinther
Journal:  Nucleic Acids Res       Date:  2017-12-15       Impact factor: 16.971

3.  siRNA Therapeutics in Ocular Diseases.

Authors:  Javier Moreno-Montañés; Anne-Marie Bleau; Tamara Martínez; Beatriz Vargas; María Victoria González; Ana Isabel Jiménez
Journal:  Methods Mol Biol       Date:  2021

4.  Hepatotoxic potential of therapeutic oligonucleotides can be predicted from their sequence and modification pattern.

Authors:  Peter H Hagedorn; Victor Yakimov; Søren Ottosen; Susanne Kammler; Niels F Nielsen; Anja M Høg; Maj Hedtjärn; Michael Meldgaard; Marianne R Møller; Henrik Orum; Troels Koch; Morten Lindow
Journal:  Nucleic Acid Ther       Date:  2013-08-16       Impact factor: 5.486

5.  Specific Inhibition of MicroRNA Processing Using L-RNA Aptamers.

Authors:  Jonathan T Sczepanski; Gerald F Joyce
Journal:  J Am Chem Soc       Date:  2015-12-21       Impact factor: 15.419

6.  Dissecting the target specificity of RNase H recruiting oligonucleotides using massively parallel reporter analysis of short RNA motifs.

Authors:  Jakob Lewin Rukov; Peter H Hagedorn; Isabel Bro Høy; Yanping Feng; Morten Lindow; Jeppe Vinther
Journal:  Nucleic Acids Res       Date:  2015-07-28       Impact factor: 16.971

Review 7.  Antisense oligonucleotides: the next frontier for treatment of neurological disorders.

Authors:  Carlo Rinaldi; Matthew J A Wood
Journal:  Nat Rev Neurol       Date:  2017-12-01       Impact factor: 42.937

8.  Binding of a structured D-RNA molecule by an L-RNA aptamer.

Authors:  Jonathan T Sczepanski; Gerald F Joyce
Journal:  J Am Chem Soc       Date:  2013-08-28       Impact factor: 15.419

9.  A structure-specific small molecule inhibits a miRNA-200 family member precursor and reverses a type 2 diabetes phenotype.

Authors:  Hafeez S Haniff; Xiaohui Liu; Yuquan Tong; Samantha M Meyer; Laurent Knerr; Malin Lemurell; Daniel Abegg; Haruo Aikawa; Alexander Adibekian; Matthew D Disney
Journal:  Cell Chem Biol       Date:  2021-07-27       Impact factor: 8.116

Review 10.  Huntington disease: new insights into molecular pathogenesis and therapeutic opportunities.

Authors:  Sarah J Tabrizi; Michael D Flower; Christopher A Ross; Edward J Wild
Journal:  Nat Rev Neurol       Date:  2020-08-14       Impact factor: 42.937
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