Literature DB >> 23047641

Ursane-type pentacyclic triterpenoids as useful platforms to discover anticancer drugs.

Jorge A R Salvador1, Vânia M Moreira, Bruno M F Gonçalves, Ana S Leal, Yongkui Jing.   

Abstract

This review highlights the potential of natural and semisynthetic ursane-type triterpenoids as candidates for the design of multi-target bioactive compounds, with focus on their anticancer effects. A brief illustration of the biosynthesis, sources, and general biological effects of the main classes of naturally occurring pentacyclic triterpenoids (PTs) are provided.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23047641     DOI： 10.1039/c2np20060k

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  20 in total

1.  Metabolomics approach for predicting response to neoadjuvant chemotherapy for colorectal cancer.

Authors:  Kai Yang; Fan Zhang; Peng Han; Zhuo-Zhong Wang; Kui Deng; Yuan-Yuan Zhang; Wei-Wei Zhao; Wei Song; Yu-Qing Cai; Kang Li; Bin-Bin Cui; Zheng-Jiang Zhu
Journal:  Metabolomics       Date:  2018-08-16       Impact factor: 4.290

2.  Synthesis and cytotoxic activity of novel A-ring cleaved ursolic acid derivatives in human non-small cell lung cancer cells.

Authors:  Vanessa I S Mendes; Geoffrey A Bartholomeusz; Mary Ayres; Varsha Gandhi; Jorge A R Salvador
Journal:  Eur J Med Chem       Date:  2016-07-22       Impact factor: 6.514

3.  Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro.

Authors:  Bo Jing; Meng Liu; Li Yang; Hai-Yan Cai; Jie-Bo Chen; Ze-Xi Li; Xi Kou; Yun-Zhao Wu; Dong-Jun Qin; Li Zhou; Jin Jin; Hu Lei; Han-Zhang Xu; Wei-Wei Wang; Ying-Li Wu
Journal:  Acta Pharmacol Sin       Date:  2017-11-23       Impact factor: 6.150

4.  Madecassic Acid Derivatives as Potential Anticancer Agents: Synthesis and Cytotoxic Evaluation.

Authors:  Ana S C Valdeira; Emad Darvishi; Girma M Woldemichael; John A Beutler; Kirk R Gustafson; Jorge A R Salvador
Journal:  J Nat Prod       Date:  2019-07-25       Impact factor: 4.050

5.  Combinatorial biosynthesis of sapogenins and saponins in Saccharomyces cerevisiae using a C-16α hydroxylase from Bupleurum falcatum.

Authors:  Tessa Moses; Jacob Pollier; Lorena Almagro; Dieter Buyst; Marc Van Montagu; María A Pedreño; José C Martins; Johan M Thevelein; Alain Goossens
Journal:  Proc Natl Acad Sci U S A       Date:  2014-01-13       Impact factor: 11.205

6.  Mangrove dolabrane-type of diterpenes tagalsins suppresses tumor growth via ROS-mediated apoptosis and ATM/ATR-Chk1/Chk2-regulated cell cycle arrest.

Authors:  Jennifer Neumann; Yi Yang; Rebecca Köhler; Marco Giaisi; Mathias Witzens-Harig; Dong Liu; Peter H Krammer; Wenhan Lin; Min Li-Weber
Journal:  Int J Cancer       Date:  2015-06-30       Impact factor: 7.396

Review 7.  Triterpene Structural Diversification by Plant Cytochrome P450 Enzymes.

Authors:  Sumit Ghosh
Journal:  Front Plant Sci       Date:  2017-11-09       Impact factor: 5.753

Review 8.  Microbial-catalyzed biotransformation of multifunctional triterpenoids derived from phytonutrients.

Authors:  Syed Adnan Ali Shah; Huey Ling Tan; Sadia Sultan; Muhammad Afifi Bin Mohd Faridz; Mohamad Azlan Bin Mohd Shah; Sharifah Nurfazilah; Munawar Hussain
Journal:  Int J Mol Sci       Date:  2014-07-07       Impact factor: 5.923

9.  Multifunctional oxidosqualene cyclases and cytochrome P450 involved in the biosynthesis of apple fruit triterpenic acids.

Authors:  Christelle M Andre; Sylvain Legay; Amélie Deleruelle; Niels Nieuwenhuizen; Matthew Punter; Cyril Brendolise; Janine M Cooney; Marc Lateur; Jean-François Hausman; Yvan Larondelle; William A Laing
Journal:  New Phytol       Date:  2016-05-23       Impact factor: 10.151

10.  Bauerenol Acetate, the Pentacyclic Triterpenoid from Tabernaemontana longipes, is an Antitrypanosomal Agent.

Authors:  Simira Carothers; Rogers Nyamwihura; Jasmine Collins; Huaisheng Zhang; HaJeung Park; William N Setzer; Ifedayo Victor Ogungbe
Journal:  Molecules       Date:  2018-02-08       Impact factor: 4.411
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.