Literature DB >> 2304629

Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach.

P Holzer1, B M Peskar, B A Peskar, R Amann.   

Abstract

It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation. This concept is supported by the present finding that capsaicin (10(-5) M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent. High-pressure liquid chromatography revealed only one peak of immunoreactivity coeluting with synthetic CGRP.

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Year:  1990        PMID： 2304629     DOI： 10.1016/0304-3940(90)90730-w

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  21 in total

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2.  Sensitizing effects of lafutidine on CGRP-containing afferent nerves in the rat stomach.

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3.  Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow.

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5.  Capsaicin-sensitive nerves modulate resting blood flow and vascular tone in rat gut.

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6.  A role for calcitonin gene-related peptide in protection against gastric ulceration.

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8.  Differential control of somatostatin messenger RNA in rat gastric corpus and antrum. Role of acid, food, and capsaicin-sensitive afferent neurons.

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9.  Nitric oxide-dependent and -independent hyperaemia due to calcitonin gene-related peptide in the rat stomach.

Authors:  P Holzer; I T Lippe; M Jocic; C Wachter; R Erb; A Heinemann
Journal:  Br J Pharmacol       Date:  1993-09       Impact factor: 8.739

Review 10.  Cholecystokinin-induced gastroprotection: a review of current protective mechanisms.

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