Literature DB >> 23046053

Several cases of work-related allergic contact dermatitis caused by isocyanates at a company manufacturing heat exchangers.

Malin Engfeldt1, Marléne Isaksson, Erik Zimerson, Magnus Bruze.   

Abstract

BACKGROUND: A 43-year-old woman was referred by her occupational health service with suspected occupational contact dermatitis. In connection with the investigation, a workplace visit was undertaken at her company, which used an adhesive based on pre-polymeric diphenylmethane diisocyanate in one of its units. During the visit, we became aware of six other employees with skin problems who were then referred to our department for investigation.
OBJECTIVES: To investigate the seven employees complaining about skin problems.
METHODS: Seven employees were patch tested with a baseline series, an isocyanate series, and a series with work material.
RESULTS: Five of seven patients had occupational contact allergy. Four reacted to isocyanate-related test preparations, and one to a cleanser used at the workplace.
CONCLUSIONS: Workplace visits constitute an important part of an occupational investigation, as they might give a broader picture of the problems at a company. In this case, it was found that 5 of 100 employees currently had or had previously had occupation-related skin problems. Owing to 'healthy worker selection', some of these patients might have been missed if we had not performed a full-scale workplace visit.
© 2012 John Wiley & Sons A/S.

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Year:  2012        PMID: 23046053     DOI: 10.1111/j.1600-0536.2012.02167.x

Source DB:  PubMed          Journal:  Contact Dermatitis        ISSN: 0105-1873            Impact factor:   6.600


  4 in total

1.  Acute 4,4'-Methylene Diphenyl Diisocyanate Exposure-Mediated Downregulation of miR-206-3p and miR-381-3p Activates Inducible Nitric Oxide Synthase Transcription by Targeting Calcineurin/NFAT Signaling in Macrophages.

Authors:  Chen-Chung Lin; Brandon F Law; Justin M Hettick
Journal:  Toxicol Sci       Date:  2020-01-01       Impact factor: 4.849

2.  MicroRNA-mediated calcineurin signaling activation induces CCL2, CCL3, CCL5, IL8, and chemotactic activities in 4,4'-methylene diphenyl diisocyanate exposed macrophages.

Authors:  Chen-Chung Lin; Brandon F Law; Justin M Hettick
Journal:  Xenobiotica       Date:  2021-12-02       Impact factor: 1.908

3.  Exposure to Toluene Di-isocyanate and Respiratory Effects in Flexible Polyurethane Foam Industries in Western India.

Authors:  S Raghavan; Rajnarayan R Tiwari; Pankaj B Doctor; Asif M Mahamad; Parveen R Mansuri
Journal:  Indian J Occup Environ Med       Date:  2021-07-09

4.  Sensitization and cross-reactivity patterns of contact allergy to diisocyanates and corresponding amines: investigation of diphenylmethane-4,4'-diisocyanate, diphenylmethane-4,4'-diamine, dicyclohexylmethane-4,4'-diisocyanate, and dicylohexylmethane-4,4'-diamine.

Authors:  Haneen Hamada; Magnus Bruze; Erik Zimerson; Marléne Isaksson; Malin Engfeldt
Journal:  Contact Dermatitis       Date:  2017-05-29       Impact factor: 6.600

  4 in total

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