Jin Zhou1. 1. Department of Hematology, the First Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150001, China. zhoujin1111@126.com
Abstract
OBJECTIVE: To summarize the clinical applications of arsenic trioxide (ATO) in the treatment of acute promyelocytic leukemia (APL), as well as non-APL malignancies and to discuss the mechanisms and adverse effects involved in ATO administration. DATA SOURCES: The data in this article were collected from PubMed and CHKD database with relevant English and Chinese articles published from 1957 to 2011, with key words including acute promyelocytic leukemia, arsenic trioxide, treatment, and mechanism. STUDY SELECTION: Articles including any information about ATO in the treatment of APL were selected. RESULTS: APL is a rare subtype of acute myeloid leukemia, with dismal prognosis under treatment with traditional chemotherapy. ATO impressively increases the complete remission rate and prolongs survival of patients with APL, with only mild and transient adverse effects. The advances in the understanding of multiple mechanisms involved in ATO treatment will benefit more cancers in future. CONCLUSION: Deeper understanding of mechanisms involved in ATO treatment may provide rationales for future clinical applications in a number of human malignancies.
OBJECTIVE: To summarize the clinical applications of arsenic trioxide (ATO) in the treatment of acute promyelocytic leukemia (APL), as well as non-APLmalignancies and to discuss the mechanisms and adverse effects involved in ATO administration. DATA SOURCES: The data in this article were collected from PubMed and CHKD database with relevant English and Chinese articles published from 1957 to 2011, with key words including acute promyelocytic leukemia, arsenic trioxide, treatment, and mechanism. STUDY SELECTION: Articles including any information about ATO in the treatment of APL were selected. RESULTS:APL is a rare subtype of acute myeloid leukemia, with dismal prognosis under treatment with traditional chemotherapy. ATO impressively increases the complete remission rate and prolongs survival of patients with APL, with only mild and transient adverse effects. The advances in the understanding of multiple mechanisms involved in ATO treatment will benefit more cancers in future. CONCLUSION: Deeper understanding of mechanisms involved in ATO treatment may provide rationales for future clinical applications in a number of humanmalignancies.
Authors: Allan H Smith; Guillermo Marshall; Yan Yuan; Craig Steinmaus; Jane Liaw; Martyn T Smith; Lily Wood; Marissa Heirich; Rebecca M Fritzemeier; Mark D Pegram; Catterina Ferreccio Journal: EBioMedicine Date: 2014-11-01 Impact factor: 8.143
Authors: Nuria Mut-Salud; Pablo Juan Álvarez; Jose Manuel Garrido; Esther Carrasco; Antonia Aránega; Fernando Rodríguez-Serrano Journal: Oxid Med Cell Longev Date: 2015-11-22 Impact factor: 6.543