OBJECTIVES: To analyse serogroup (Sg)- and finetype-specific invasive meningococcal disease burden (IMD) in Germany, 2002-2010, with emphasis on effects of vaccination with conjugate SgC vaccines targeting one-year old children since 2006, including individual-based catch-up to 17 years of age. METHODS: Serogroup- and age-specific IMD incidence and trends were calculated using statutory surveillance data. The national reference laboratory performed genetic finetyping. Vaccination uptake data were obtained from school entry surveys and prescription monitoring. RESULTS: In persons <25 years, SgB and SgC IMD incidence decreased significantly from 0.63 to 0.32/100,000 and 0.26 to 0.10/100,000, respectively. The decline was significantly steeper for SgC than SgB in 1-5 year-olds, the primary vaccination target group, but not other ages. The slope of the SgC incidence curves was similar before and after vaccination implementation in all age groups; however, the decrease in incidence was steeper in states with higher vaccination uptake. Declining SgC incidence was associated with decreased SgC finetype diversity. An increase in SgY incidence was limited to adults. CONCLUSIONS: Results suggest effects of the German SgC vaccination strategy are limited, although interpretation is complicated by already low and decreasing incidence before vaccination. More effective use of vaccination resources might be achieved by rigorously targeting adolescents in addition to 1-year-olds.
OBJECTIVES: To analyse serogroup (Sg)- and finetype-specific invasive meningococcal disease burden (IMD) in Germany, 2002-2010, with emphasis on effects of vaccination with conjugate SgC vaccines targeting one-year old children since 2006, including individual-based catch-up to 17 years of age. METHODS: Serogroup- and age-specific IMD incidence and trends were calculated using statutory surveillance data. The national reference laboratory performed genetic finetyping. Vaccination uptake data were obtained from school entry surveys and prescription monitoring. RESULTS: In persons <25 years, SgB and SgC IMD incidence decreased significantly from 0.63 to 0.32/100,000 and 0.26 to 0.10/100,000, respectively. The decline was significantly steeper for SgC than SgB in 1-5 year-olds, the primary vaccination target group, but not other ages. The slope of the SgC incidence curves was similar before and after vaccination implementation in all age groups; however, the decrease in incidence was steeper in states with higher vaccination uptake. Declining SgC incidence was associated with decreased SgC finetype diversity. An increase in SgY incidence was limited to adults. CONCLUSIONS: Results suggest effects of the German SgC vaccination strategy are limited, although interpretation is complicated by already low and decreasing incidence before vaccination. More effective use of vaccination resources might be achieved by rigorously targeting adolescents in addition to 1-year-olds.
Authors: Volker Vetter; Roger Baxter; Gülhan Denizer; Marco A P Sáfadi; Sven-Arne Silfverdal; Andrew Vyse; Ray Borrow Journal: Expert Rev Vaccines Date: 2016-03-04 Impact factor: 5.217
Authors: Maria Drayß; Heike Claus; Kerstin Hubert; Katrin Thiel; Anja Berger; Andreas Sing; Mark van der Linden; Ulrich Vogel; Thiên-Trí Lâm Journal: PLoS One Date: 2019-02-08 Impact factor: 3.240
Authors: Carina Brehony; Caroline L Trotter; Mary E Ramsay; Manosree Chandra; Keith A Jolley; Arie van der Ende; Françoise Carion; Lene Berthelsen; Steen Hoffmann; Hjördís Harðardóttir; Julio A Vazquez; Karen Murphy; Maija Toropainen; Manuela Caniça; Eugenia Ferreira; Mathew Diggle; Giles F Edwards; Muhamed-Kheir Taha; Paola Stefanelli; Paula Kriz; Steve J Gray; Andrew J Fox; Susanne Jacobsson; Heike Claus; Ulrich Vogel; Georgina Tzanakaki; Sigrid Heuberger; Dominique A Caugant; Matthias Frosch; Martin C J Maiden Journal: Clin Vaccine Immunol Date: 2014-04-02
Authors: Juan Carlos Tejedor; Jerzy Brzostek; Ryszard Konior; Detlef Grunert; Devayani Kolhe; Yaela Baine; Marie Van Der Wielen Journal: Clin Vaccine Immunol Date: 2016-07-05