Literature DB >> 2304220

Underreporting research is scientific misconduct.

I Chalmers1.   

Abstract

Substantial numbers of clinical trials are never reported in print, and among those that are, many are not reported in sufficient detail to enable judgments to be made about the validity of their results. Failure to publish an adequate account of a well-designed clinical trial is a form of scientific misconduct that can lead those caring for patients to make inappropriate treatment decisions. Investigators, research ethics committees, funding bodies, and scientific editors all have responsibilities to reduce underreporting of clinical trials. An extended use of prospective registration of trials at inception, as well as benefiting clinical research in other ways, could help people to play their respective roles in reducing underreporting of clinical trials.

Entities:  

Keywords:  Analytical Approach; Biomedical and Behavioral Research; Empirical Approach

Mesh:

Year:  1990        PMID: 2304220

Source DB:  PubMed          Journal:  JAMA        ISSN: 0098-7484            Impact factor:   56.272


  147 in total

1.  Time to register randomised trials. The case is now unanswerable.

Authors:  R Horton; R Smith
Journal:  BMJ       Date:  1999-10-02

2.  Maintaining the integrity of the scientific record.

Authors:  R Smith
Journal:  BMJ       Date:  2001-09-15

3.  Applied pharmacoeconomics. When can publication be legitimately withheld?

Authors:  G C Yee; A L Hillman
Journal:  Pharmacoeconomics       Date:  1997-11       Impact factor: 4.981

4.  Parafraud in biology.

Authors:  Harold Hillman
Journal:  Sci Eng Ethics       Date:  1997-04       Impact factor: 3.525

Review 5.  Dobutamine for patients with severe heart failure: a systematic review and meta-analysis of randomised controlled trials.

Authors:  Catherine L Tacon; John McCaffrey; Anthony Delaney
Journal:  Intensive Care Med       Date:  2011-12-08       Impact factor: 17.440

6.  [Psychiatrists and the pharmaceutical industry].

Authors:  H Helmchen
Journal:  Nervenarzt       Date:  2003-11       Impact factor: 1.214

7.  Getting it right: industry sponsorship and medical research.

Authors:  Patricia Baird
Journal:  CMAJ       Date:  2003-05-13       Impact factor: 8.262

Review 8.  Pharmaceutical industry sponsorship and research outcome and quality: systematic review.

Authors:  Joel Lexchin; Lisa A Bero; Benjamin Djulbegovic; Otavio Clark
Journal:  BMJ       Date:  2003-05-31

Review 9.  Evidence b(i)ased medicine--selective reporting from studies sponsored by pharmaceutical industry: review of studies in new drug applications.

Authors:  Hans Melander; Jane Ahlqvist-Rastad; Gertie Meijer; Björn Beermann
Journal:  BMJ       Date:  2003-05-31

10.  Conflict of interest and medical publication.

Authors:  Marcus M Reidenberg
Journal:  Sci Eng Ethics       Date:  2002-07       Impact factor: 3.525

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