PURPOSE: To investigate the posterior segment in cases of clinically evident intraocular inflammation for punctate reflections consistent with that expected to arise from inflammatory cells. METHODS: Patients with ocular inflammatory diseases imaged with spectral-domain optical coherence tomography (SD-OCT) were retrospectively reviewed. RESULTS: There were 7 patients with mean age of 66.7 years, and the diagnosis was toxoplasmosis in 5 eyes, multiple evanescent white dot syndrome in 1 eye, and posttraumatic outer retinitis in 1 eye. At baseline, the SD-OCT showed vitreous cells as numerous punctate spots in the vitreous in all seven eyes. The SD-OCT also showed similar-sized hyperreflective dots in the retina in all seven eyes. During follow-up, reduced vitreous cellular infiltration was correlated with a decrease in the number of the punctate spots visible by SD-OCT. CONCLUSION: Eyes with intraocular inflammation had SD-OCT images of the vitreous containing punctate spots of a size consistent with that expected from inflammatory cells. Similarly sized punctate spots were seen within the retina in regions of retinitis. Additional characterization of the optical section should permit stereological estimations of actual cell counts per unit volume.
PURPOSE: To investigate the posterior segment in cases of clinically evident intraocular inflammation for punctate reflections consistent with that expected to arise from inflammatory cells. METHODS:Patients with ocular inflammatory diseases imaged with spectral-domain optical coherence tomography (SD-OCT) were retrospectively reviewed. RESULTS: There were 7 patients with mean age of 66.7 years, and the diagnosis was toxoplasmosis in 5 eyes, multiple evanescent white dot syndrome in 1 eye, and posttraumatic outer retinitis in 1 eye. At baseline, the SD-OCT showed vitreous cells as numerous punctate spots in the vitreous in all seven eyes. The SD-OCT also showed similar-sized hyperreflective dots in the retina in all seven eyes. During follow-up, reduced vitreous cellular infiltration was correlated with a decrease in the number of the punctate spots visible by SD-OCT. CONCLUSION: Eyes with intraocular inflammation had SD-OCT images of the vitreous containing punctate spots of a size consistent with that expected from inflammatory cells. Similarly sized punctate spots were seen within the retina in regions of retinitis. Additional characterization of the optical section should permit stereological estimations of actual cell counts per unit volume.
Authors: Pearse A Keane; Michael Karampelas; Dawn A Sim; Srinivas R Sadda; Adnan Tufail; H Nida Sen; Robert B Nussenblatt; Andrew D Dick; Richard W Lee; Philip I Murray; Carlos E Pavesio; Alastair K Denniston Journal: Ophthalmology Date: 2014-05-15 Impact factor: 12.079
Authors: Barbara Berasategui; Alex Fonollosa; Joseba Artaraz; Ioana Ruiz-Arruza; Jose Ríos; Jessica Matas; Victor Llorenç; David Diaz-Valle; Marina Sastre-Ibañez; Pedro Arriola-Villalobos; Alfredo Adan Journal: BMC Ophthalmol Date: 2018-07-20 Impact factor: 2.209
Authors: Wilfried Glatz; Gernot Steinwender; Lisa Tarmann; Eva Maria Malle; Marlene Schörkhuber; Werner Wackernagel; Goran Petrovski; Andreas Wedrich; Domagoj Ivastinovic Journal: PLoS One Date: 2017-12-15 Impact factor: 3.240
Authors: Scott H Greenwald; Emily E Brown; Michael J Scandura; Erin Hennessey; Raymond Farmer; Basil S Pawlyk; Ru Xiao; Luk H Vandenberghe; Eric A Pierce Journal: Mol Ther Methods Clin Dev Date: 2020-07-09 Impact factor: 6.698