Literature DB >> 23041777

Evaluation of dopamine transporters and D2 receptors in hemiparkinsonian rat brains in vivo using consecutive PET scans of [18F]FPCIT and [18F]fallypride.

Jae Yong Choi1, Chul Hoon Kim, Tae Joo Jeon, Won Gil Cho, Jin Suk Lee, Soo Jin Lee, Tae Hyun Choi, Byoung Soo Kim, Chi Hoon Yi, Youngbeom Seo, Dae Ik Yi, Sang Jin Han, Minkyung Lee, Dong Goo Kim, Jong Doo Lee, Gwangil An, Young Hoon Ryu.   

Abstract

The aim of this study was to investigate dopaminergic function in unilaterally lesioned 6-OHDA rats by dual PET radioligands: [(18)F]FPCIT (a dopamine transporter imaging radioligand) and [(18)F]fallypride (a dopamine D2 receptors imaging radioligand). As a result, the brain uptake of [(18)F]FPCIT was significantly reduced and that of [(18)F]fallypride was increased in the ipsilateral striatum (lesion side) of the 6-OHDA rats. These findings implicated that dopamine transporter is down-regulated and dopamine D2 receptor is up-regulated in this hemiparkinsonian rat model.
Copyright © 2012 Elsevier Ltd. All rights reserved.

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Year:  2012        PMID： 23041777     DOI： 10.1016/j.apradiso.2012.08.005

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  6 in total

1.  Environmental enrichment enhances synaptic plasticity by internalization of striatal dopamine transporters.

Authors:  Myung-Sun Kim; Ji Hea Yu; Chul Hoon Kim; Jae Yong Choi; Jung Hwa Seo; Min-Young Lee; Chi Hoon Yi; Tae Hyun Choi; Young Hoon Ryu; Jong Eun Lee; Bae Hwan Lee; Hyongbum Kim; Sung-Rae Cho
Journal:  J Cereb Blood Flow Metab       Date:  2015-11-02       Impact factor: 6.200

2.  Olfactory Bulb D2/D3 Receptor Availability after Intrastriatal Botulinum Neurotoxin-A Injection in a Unilateral 6-OHDA Rat Model of Parkinson's Disease.

Authors:  Teresa Alberts; Veronica Antipova; Carsten Holzmann; Alexander Hawlitschka; Oliver Schmitt; Jens Kurth; Jan Stenzel; Tobias Lindner; Bernd J Krause; Andreas Wree; Martin Witt
Journal:  Toxins (Basel)       Date:  2022-01-25       Impact factor: 4.546

3.  Botulinum Neurotoxin A Injected Ipsilaterally or Contralaterally into the Striatum in the Rat 6-OHDA Model of Unilateral Parkinson's Disease Differently Affects Behavior.

Authors:  Veronica A Antipova; Carsten Holzmann; Oliver Schmitt; Andreas Wree; Alexander Hawlitschka
Journal:  Front Behav Neurosci       Date:  2017-06-21       Impact factor: 3.558

4.  Preclinical Analysis of Fetal Human Mesencephalic Neural Progenitor Cell Lines: Characterization and Safety In Vitro and In Vivo.

Authors:  Jisook Moon; Sigrid C Schwarz; Hyun-Seob Lee; Jun Mo Kang; Young-Eun Lee; Bona Kim; Mi-Young Sung; Günter Höglinger; Florian Wegner; Jin Su Kim; Hyung-Min Chung; Sung Woon Chang; Kwang Yul Cha; Kwang-Soo Kim; Johannes Schwarz
Journal:  Stem Cells Transl Med       Date:  2016-09-02       Impact factor: 6.940

5.  [18F]fallypride-PET/CT Analysis of the Dopamine D₂/D₃ Receptor in the Hemiparkinsonian Rat Brain Following Intrastriatal Botulinum Neurotoxin A Injection.

Authors:  Teresa Mann; Jens Kurth; Alexander Hawlitschka; Jan Stenzel; Tobias Lindner; Stefan Polei; Alexander Hohn; Bernd J Krause; Andreas Wree
Journal:  Molecules       Date:  2018-03-06       Impact factor: 4.411

6.  Acetylcholine Neurotransmitter Receptor Densities in the Striatum of Hemiparkinsonian Rats Following Botulinum Neurotoxin-A Injection.

Authors:  Teresa Mann; Karl Zilles; Felix Klawitter; Markus Cremer; Alexander Hawlitschka; Nicola Palomero-Gallagher; Oliver Schmitt; Andreas Wree
Journal:  Front Neuroanat       Date:  2018-08-10       Impact factor: 3.856
  6 in total

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