BACKGROUND: Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central nervous system (CNS) with complex pathogenesis. IL-21/IL-21R regulates activation, proliferation and survival of both T cells and B cells, which are involved in the pathogenesis of NMO and MS. High levels of serum IL-21 were observed in NMO patients. However, concentration of cerebrospinal fluid (CSF) IL-21 in MS and NMO patients still remain unknown. OBJECT: To detect the CSF concentration of IL-21 in NMO and MS patients and to evaluate its relationship with disease activity, particularly concerned about its impact on humoral immunity. METHODS: CSF IL-21 was detected by an enzyme-linked immunosorbent assay (ELISA) in NMO patients (n=21), MS patients (n=20) and controls (n=16). RESULTS: CSF concentration of the IL-21 was noticeably elevated in NMO (p=0.012) and borderline significantly increased in MS (p=0.115). In addition, this occurrence was associated with humoral immune activity as shown by a correlation between IL-21 and complement in NMO cohort (p=0.023) and high IL-21 levels in autoantibody-positive subgroup (p=0.027). CONCLUSIONS: The concentration of CSF IL-21 was noticeably elevated and might have a positive correlation with humoral immune activity in NMO.
BACKGROUND:Neuromyelitis optica (NMO) and multiple sclerosis (MS) are inflammatory demyelinating diseases of human central nervous system (CNS) with complex pathogenesis. IL-21/IL-21R regulates activation, proliferation and survival of both T cells and B cells, which are involved in the pathogenesis of NMO and MS. High levels of serum IL-21 were observed in NMO patients. However, concentration of cerebrospinal fluid (CSF) IL-21 in MS and NMO patients still remain unknown. OBJECT: To detect the CSF concentration of IL-21 in NMO and MS patients and to evaluate its relationship with disease activity, particularly concerned about its impact on humoral immunity. METHODS: CSF IL-21 was detected by an enzyme-linked immunosorbent assay (ELISA) in NMO patients (n=21), MS patients (n=20) and controls (n=16). RESULTS: CSF concentration of the IL-21 was noticeably elevated in NMO (p=0.012) and borderline significantly increased in MS (p=0.115). In addition, this occurrence was associated with humoral immune activity as shown by a correlation between IL-21 and complement in NMO cohort (p=0.023) and high IL-21 levels in autoantibody-positive subgroup (p=0.027). CONCLUSIONS: The concentration of CSF IL-21 was noticeably elevated and might have a positive correlation with humoral immune activity in NMO.
Authors: P O Barros; T Cassano; J Hygino; T B Ferreira; N Centurião; T M Kasahara; R M Andrade; U C Linhares; A F B Andrade; C C F Vasconcelos; R Alvarenga; R Marignier; C A M Bento Journal: Clin Exp Immunol Date: 2015-12-01 Impact factor: 4.330
Authors: Timothy W Phares; Krista D DiSano; David R Hinton; Mihyun Hwang; Allan J Zajac; Stephen A Stohlman; Cornelia C Bergmann Journal: J Neuroimmunol Date: 2013-08-06 Impact factor: 3.478
Authors: Ilana Katz Sand; Michelle T Fabian; Russell Telford; Thomas A Kraus; Mirna Chehade; Madhan Masilamani; Thomas Moran; Colleen Farrell; Shelly Ebel; Lawrence J Cook; John Rose; Fred D Lublin Journal: Neurol Neuroimmunol Neuroinflamm Date: 2018-02-02