Literature DB >> 23038269

Structure, function, and modulation of GABA(A) receptors.

Erwin Sigel1, Michael E Steinmann.   

Abstract

The GABA(A) receptors are the major inhibitory neurotransmitter receptors in mammalian brain. Each isoform consists of five homologous or identical subunits surrounding a central chloride ion-selective channel gated by GABA. How many isoforms of the receptor exist is far from clear. GABA(A) receptors located in the postsynaptic membrane mediate neuronal inhibition that occurs in the millisecond time range; those located in the extrasynaptic membrane respond to ambient GABA and confer long-term inhibition. GABA(A) receptors are responsive to a wide variety of drugs, e.g. benzodiazepines, which are often used for their sedative/hypnotic and anxiolytic effects.

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Year:  2012        PMID： 23038269      PMCID： PMC3504738          DOI： 10.1074/jbc.R112.386664

Source DB:  PubMed          Journal:  J Biol Chem        ISSN： 0021-9258            Impact factor:   5.157


  95 in total

Review 1.  Nicotinic receptors at the amino acid level.

Authors:  P J Corringer; N Le Novère; J P Changeux
Journal:  Annu Rev Pharmacol Toxicol       Date:  2000       Impact factor: 13.820

2.  GABA(A) receptor epsilon and theta subunits display unusual structural variation between species and are enriched in the rat locus ceruleus.

Authors:  S T Sinkkonen; M C Hanna; E F Kirkness; E R Korpi
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

3.  Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.

Authors:  K Brejc; W J van Dijk; R V Klaassen; M Schuurmans; J van Der Oost; A B Smit; T K Sixma
Journal:  Nature       Date:  2001-05-17       Impact factor: 49.962

4.  Molecular and neuronal substrate for the selective attenuation of anxiety.

Authors:  K Löw; F Crestani; R Keist; D Benke; I Brünig; J A Benson; J M Fritschy; T Rülicke; H Bluethmann; H Möhler; U Rudolph
Journal:  Science       Date:  2000-10-06       Impact factor: 47.728

5.  Unravelling the role of GABAA receptor subtypes in distinct neurons and behaviour.

Authors:  Werner Sieghart
Journal:  J Physiol       Date:  2012-05-15       Impact factor: 5.182

6.  Structure and dynamics of the GABA binding pocket: A narrowing cleft that constricts during activation.

Authors:  D A Wagner; C Czajkowski
Journal:  J Neurosci       Date:  2001-01-01       Impact factor: 6.167

7.  Benzodiazepine actions mediated by specific gamma-aminobutyric acid(A) receptor subtypes.

Authors:  U Rudolph; F Crestani; D Benke; I Brünig; J A Benson; J M Fritschy; J R Martin; H Bluethmann; H Möhler
Journal:  Nature       Date:  1999-10-21       Impact factor: 49.962

8.  A novel class of ligand-gated ion channel is activated by Zn2+.

Authors:  Paul A Davies; Wei Wang; Tim G Hales; Ewen F Kirkness
Journal:  J Biol Chem       Date:  2002-10-14       Impact factor: 5.157

9.  Molecular targets for the myorelaxant action of diazepam.

Authors:  F Crestani; K Löw; R Keist; M Mandelli; H Möhler; U Rudolph
Journal:  Mol Pharmacol       Date:  2001-03       Impact factor: 4.436

10.  Cysteine mutants as chemical sensors for ligand-receptor interactions.

Authors:  B Foucaud; P Perret; T Grutter; M Goeldner
Journal:  Trends Pharmacol Sci       Date:  2001-04       Impact factor: 14.819
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  229 in total

1.  Neurotoxins from snake venoms and α-conotoxin ImI inhibit functionally active ionotropic γ-aminobutyric acid (GABA) receptors.

Authors:  Denis S Kudryavtsev; Irina V Shelukhina; Lina V Son; Lucy O Ojomoko; Elena V Kryukova; Ekaterina N Lyukmanova; Maxim N Zhmak; Dmitry A Dolgikh; Igor A Ivanov; Igor E Kasheverov; Vladislav G Starkov; Joachim Ramerstorfer; Werner Sieghart; Victor I Tsetlin; Yuri N Utkin
Journal:  J Biol Chem       Date:  2015-07-28       Impact factor: 5.157

2.  Three-Step Test System for the Identification of Novel GABAA Receptor Modulating Food Plants.

Authors:  Sümeyye Sahin; Volker Eulenburg; Wolfgang Kreis; Carmen Villmann; Monika Pischetsrieder
Journal:  Plant Foods Hum Nutr       Date:  2016-12       Impact factor: 3.921

Review 3.  MicroRNAs in neuronal communication.

Authors:  Guilherme Shigueto Vilar Higa; Erica de Sousa; Lais Takata Walter; Erika Reime Kinjo; Rodrigo Ribeiro Resende; Alexandre Hiroaki Kihara
Journal:  Mol Neurobiol       Date:  2014-01-03       Impact factor: 5.590

4.  Anti-Tremor Action of Subtype Selective Positive Allosteric Modulators of GABAA Receptors in a Rat Model of Essential Tremors.

Authors:  Dipak V Amrutkar; Tino Dyhring; Thomas A Jacobsen; Janus S Larsen; Karin Sandager-Nielsen
Journal:  Cerebellum       Date:  2020-04       Impact factor: 3.847

5.  Potentiation of a neuronal nicotinic receptor via pseudo-agonist site.

Authors:  Simone Mazzaferro; Isabel Bermudez; Steven M Sine
Journal:  Cell Mol Life Sci       Date:  2019-01-01       Impact factor: 9.261

6.  Alphaxalone Binds in Inner Transmembrane β+-α- Interfaces of α1β3γ2 γ-Aminobutyric Acid Type A Receptors.

Authors:  Alexis M Ziemba; Andrea Szabo; David W Pierce; Marian Haburcak; Alex T Stern; Anahita Nourmahnad; Elizabeth S Halpin; Stuart A Forman
Journal:  Anesthesiology       Date:  2018-02       Impact factor: 7.892

7.  Vesicular GABA Transporter Is Necessary for Transplant-Induced Critical Period Plasticity in Mouse Visual Cortex.

Authors:  Rashi Priya; Benjamin Rakela; Megumi Kaneko; Julien Spatazza; Philip Larimer; Mahmood S Hoseini; Andrea R Hasenstaub; Arturo Alvarez-Buylla; Michael P Stryker
Journal:  J Neurosci       Date:  2019-01-31       Impact factor: 6.167

8.  Anticonvulsive Activity in Audiogenic DBA/2 Mice of 1,4-Benzodiazepines and 1,5-Benzodiazepines with Different Activities at Cerebellar Granule Cell GABAA Receptors.

Authors:  Elena Gatta; Aroldo Cupello; Mario Di Braccio; Giancarlo Grossi; Mauro Robello; Francesca Scicchitano; Emilio Russo; Giovambattista De Sarro
Journal:  J Mol Neurosci       Date:  2016-09-15       Impact factor: 3.444

9.  Does acute heat stress differentially-modulate expression of ionotropic neurotransmitter receptors in the RVLM of young and aged F344 rats?

Authors:  Hitesh N Pawar; Sivasai Balivada; Michael J Kenney
Journal:  Neurosci Lett       Date:  2018-10-01       Impact factor: 3.046

10.  Identification of an Inhibitory Alcohol Binding Site in GABAA ρ1 Receptors.

Authors:  Cecilia M Borghese; Carlos I Ruiz; Ui S Lee; Madeline A Cullins; Edward J Bertaccini; James R Trudell; R Adron Harris
Journal:  ACS Chem Neurosci       Date:  2015-11-25       Impact factor: 4.418
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