Literature DB >> 23037595

Making the cut: intramembrane cleavage by a rhomboid protease promotes ERAD.

Ethan J Greenblatt1, James A Olzmann, Ron R Kopito.   

Abstract

Endoplasmic reticulum–associated degradation (ERAD) is a cellular protein quality-control process that disposes of proteasomal substrates from the early secretory pathway. Recent work shows that the endoplasmic reticulum–resident rhomboid protease RHBDL4 facilitates ERAD by recognizing and cleaving integral membrane substrates. The work indicates that intramembrane proteolysis may have a general role in the extraction of misfolded membrane proteins from the endoplasmic reticulum.

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Year:  2012        PMID： 23037595      PMCID： PMC3616633          DOI： 10.1038/nsmb.2398

Source DB:  PubMed          Journal:  Nat Struct Mol Biol        ISSN： 1545-9985            Impact factor:   15.369


  22 in total

1.  p97 functions as an auxiliary factor to facilitate TM domain extraction during CFTR ER-associated degradation.

Authors:  Eric J Carlson; David Pitonzo; William R Skach
Journal:  EMBO J       Date:  2006-09-14       Impact factor: 11.598

Review 2.  Signal integration in the endoplasmic reticulum unfolded protein response.

Authors:  David Ron; Peter Walter
Journal:  Nat Rev Mol Cell Biol       Date:  2007-07       Impact factor: 94.444

3.  The alpha chain of the T cell antigen receptor is degraded in the cytosol.

Authors:  J B Huppa; H L Ploegh
Journal:  Immunity       Date:  1997-07       Impact factor: 31.745

4.  Signal peptide peptidase is required for dislocation from the endoplasmic reticulum.

Authors:  Joana Loureiro; Brendan N Lilley; Eric Spooner; Vanessa Noriega; Domenico Tortorella; Hidde L Ploegh
Journal:  Nature       Date:  2006-05-31       Impact factor: 49.962

5.  Ubiquitin-dependent intramembrane rhomboid protease promotes ERAD of membrane proteins.

Authors:  Lina Fleig; Nina Bergbold; Priyanka Sahasrabudhe; Beate Geiger; Lejla Kaltak; Marius K Lemberg
Journal:  Mol Cell       Date:  2012-07-12       Impact factor: 17.970

6.  Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein.

Authors:  T W Loo; D M Clarke
Journal:  J Biol Chem       Date:  1998-12-04       Impact factor: 5.157

7.  A conserved mechanism for extracellular signaling in eukaryotes and prokaryotes.

Authors:  Marco Gallio; Gwen Sturgill; Philip Rather; Per Kylsten
Journal:  Proc Natl Acad Sci U S A       Date:  2002-09-09       Impact factor: 11.205

8.  Degradation of HMG-CoA reductase in vitro. Cleavage in the membrane domain by a membrane-bound cysteine protease.

Authors:  T Moriyama; S K Sather; T P McGee; R D Simoni
Journal:  J Biol Chem       Date:  1998-08-21       Impact factor: 5.157

9.  Substrate specificity of rhomboid intramembrane proteases is governed by helix-breaking residues in the substrate transmembrane domain.

Authors:  Sinisa Urban; Matthew Freeman
Journal:  Mol Cell       Date:  2003-06       Impact factor: 17.970

10.  Evidence that endoplasmic reticulum (ER)-associated degradation of cystic fibrosis transmembrane conductance regulator is linked to retrograde translocation from the ER membrane.

Authors:  X Xiong; E Chong; W R Skach
Journal:  J Biol Chem       Date:  1999-01-29       Impact factor: 5.157
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  12 in total

Review 1.  Ubiquitin-dependent protein degradation at the yeast endoplasmic reticulum and nuclear envelope.

Authors:  Dimitrios Zattas; Mark Hochstrasser
Journal:  Crit Rev Biochem Mol Biol       Date:  2014-09-18       Impact factor: 8.250

2.  Entamoeba histolytica rhomboid protease 1 has a role in migration and motility as validated by two independent genetic approaches.

Authors:  Elena Rastew; Laura Morf; Upinder Singh
Journal:  Exp Parasitol       Date:  2015-04-15       Impact factor: 2.011

Review 3.  Ubiquitin-dependent protein degradation at the endoplasmic reticulum and nuclear envelope.

Authors:  Adrian B Mehrtash; Mark Hochstrasser
Journal:  Semin Cell Dev Biol       Date:  2018-10-09       Impact factor: 7.727

Review 4.  Endoplasmic Reticulum-Associated Degradation and Lipid Homeostasis.

Authors:  Julian Stevenson; Edmond Y Huang; James A Olzmann
Journal:  Annu Rev Nutr       Date:  2016-05-26       Impact factor: 11.848

Review 5.  The role of rhomboid superfamily members in protein homeostasis: Mechanistic insight and physiological implications.

Authors:  Rachel R Kandel; Sonya E Neal
Journal:  Biochim Biophys Acta Mol Cell Res       Date:  2020-07-06       Impact factor: 5.011

6.  Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97.

Authors:  Hanneke Hoelen; Arnaud Zaldumbide; Wouter F van Leeuwen; Ellen C W Torfs; Marten A Engelse; Chopie Hassan; Robert Jan Lebbink; Eelco J de Koning; Maaike E Resssing; Arnoud H de Ru; Peter A van Veelen; Rob C Hoeben; Bart O Roep; Emmanuel J H J Wiertz
Journal:  PLoS One       Date:  2015-06-24       Impact factor: 3.240

Review 7.  Protein quality control in the endoplasmic reticulum.

Authors:  Paul-Albert Koenig; Hidde L Ploegh
Journal:  F1000Prime Rep       Date:  2014-07-08

8.  Cleavage by signal peptide peptidase is required for the degradation of selected tail-anchored proteins.

Authors:  Jessica M Boname; Stuart Bloor; Michal P Wandel; James A Nathan; Robin Antrobus; Kevin S Dingwell; Teresa L Thurston; Duncan L Smith; James C Smith; Felix Randow; Paul J Lehner
Journal:  J Cell Biol       Date:  2014-06-23       Impact factor: 10.539

9.  Mouse Mammary Tumor Virus Signal Peptide Uses a Novel p97-Dependent and Derlin-Independent Retrotranslocation Mechanism To Escape Proteasomal Degradation.

Authors:  Hyewon Byun; Poulami Das; Houqing Yu; Alejandro Aleman; Mary M Lozano; Andreas Matouschek; Jaquelin P Dudley
Journal:  MBio       Date:  2017-03-28       Impact factor: 7.867

10.  Derlin rhomboid pseudoproteases employ substrate engagement and lipid distortion to enable the retrotranslocation of ERAD membrane substrates.

Authors:  Anahita Nejatfard; Nicholas Wauer; Satarupa Bhaduri; Adam Conn; Saroj Gourkanti; Narinderbir Singh; Tiffany Kuo; Rachel Kandel; Rommie E Amaro; Sonya E Neal
Journal:  Cell Rep       Date:  2021-10-19       Impact factor: 9.423
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