| Literature DB >> 23036699 |
Vanessa Kiyomi Ota1, Letícia Nery Spíndola, Ary Gadelha, Airton Ferreira dos Santos Filho, Marcos Leite Santoro, Denise Maria Christofolini, Fernanda Teixeira Bellucco, Ândrea Kely Ribeiro-dos-Santos, Sidney Santos, Jair de Jesus Mari, Maria Isabel Melaragno, Rodrigo Affonseca Bressan, Marilia de Arruda Cardoso Smith, Sintia Iole Belangero.
Abstract
We investigated the association of dopamine receptor D1 gene (DRD1) rs4532 polymorphism with antipsychotic treatment response in schizophrenia. We have analyzed 124 patients with schizophrenia, consisting of 59 treatment resistant (TR) and 65 non-TR. We found an association between G-allele and TR schizophrenia (p=0.001; adjusted OR=2.71). Setting the common AA-genotype as reference, the GG-homozygous presented a five-fold risk compared to AA-homozygous (p=0.010; OR=5.56) with an intermediate result for AG-genotype (p=0.030; adjusted OR=2.64). The DRD1 rs4532 polymorphism showed a dose-response gradient with increased risk for treatment resistance and may be a potential pharmacogenetic marker for antipsychotic drug treatment response.Entities:
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Year: 2012 PMID： 23036699 DOI： 10.1016/j.schres.2012.08.003
Source DB: PubMed Journal: Schizophr Res ISSN： 0920-9964 Impact factor: 4.939