OBJECTIVES: Previous studies in HIV-infected populations have yielded conflicting results on the effect of antiretroviral therapy (ART) on cognition. Our objective was to investigate the effect of several years of ART with stable central nervous system penetration effectiveness (CPE) score on neuropsychological performance in HIV-infected individuals. METHODS: We analysed a clinical cohort of HIV-infected patients who initiated ART between June 2003 and December 2006 and maintained stable CPE scores. Patients were evaluated with a short neuropsychological battery. Using linear regression, we examined the relationship between results of cognitive tests and CPE scores in all patients. RESULTS: Patients were divided into three similarly sized groups (CPE ≤ 1, CPE between 1.5 and 2.5, and CPE ≥ 2.5). We found that ART with high CPE scores was associated with poorer executive performances in HIV-1-infected patients. CONCLUSION: These results suggest that cognitive performance in treated HIV-infected patients could be influenced by ART.
OBJECTIVES: Previous studies in HIV-infected populations have yielded conflicting results on the effect of antiretroviral therapy (ART) on cognition. Our objective was to investigate the effect of several years of ART with stable central nervous system penetration effectiveness (CPE) score on neuropsychological performance in HIV-infected individuals. METHODS: We analysed a clinical cohort of HIV-infectedpatients who initiated ART between June 2003 and December 2006 and maintained stable CPE scores. Patients were evaluated with a short neuropsychological battery. Using linear regression, we examined the relationship between results of cognitive tests and CPE scores in all patients. RESULTS:Patients were divided into three similarly sized groups (CPE ≤ 1, CPE between 1.5 and 2.5, and CPE ≥ 2.5). We found that ART with high CPE scores was associated with poorer executive performances in HIV-1-infectedpatients. CONCLUSION: These results suggest that cognitive performance in treated HIV-infectedpatients could be influenced by ART.
Authors: Laurie M Baker; Robert H Paul; Jodi M Heaps-Woodruff; Jee Yoon Chang; Mario Ortega; Zachary Margolin; Christina Usher; Brian Basco; Sarah Cooley; Beau M Ances Journal: J Neuroimmune Pharmacol Date: 2015-04-22 Impact factor: 4.147
Authors: Alicia González-Baeza; Fernando Carvajal; Carmen Bayón; Ignacio Pérez-Valero; Miriam Estébanez; Jose I Bernardino; Susana Monge; María Lagarde; Asunción Hernando; Francisco Arnalich; José R Arribas Journal: J Neurovirol Date: 2014-04-24 Impact factor: 2.643
Authors: Brigid K Jensen; Hubert Monnerie; Maggie V Mannell; Patrick J Gannon; Cagla Akay Espinoza; Michelle A Erickson; Annadora J Bruce-Keller; Benjamin B Gelman; Lisa A Briand; R Christopher Pierce; Kelly L Jordan-Sciutto; Judith B Grinspan Journal: J Neuropathol Exp Neurol Date: 2015-11 Impact factor: 3.685
Authors: Patrick J Gannon; Cagla Akay-Espinoza; Alan C Yee; Lisa A Briand; Michelle A Erickson; Benjamin B Gelman; Yan Gao; Norman J Haughey; M Christine Zink; Janice E Clements; Nicholas S Kim; Gabriel Van De Walle; Brigid K Jensen; Robert Vassar; R Christopher Pierce; Alexander J Gill; Dennis L Kolson; J Alan Diehl; Joseph L Mankowski; Kelly L Jordan-Sciutto Journal: Am J Pathol Date: 2017-01 Impact factor: 4.307