PURPOSE: The identification of variables associated with health-related quality of life (HRQoL) in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) would improve surgical decision-making and post-operatory follow-up in this group of patients. METHODS: We analyzed the independent association between the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) of 81 consecutive patients with refractory MTLE-HS. The clinical, demographic, radiological and electrophysiological variables were analyzed by multiple linear regression analysis. KEY FINDINGS: Approximately 36% (adjusted R(2)=0.36; R coefficient=0.66) of the QOLIE-31 overall score variance was explained by the history of initial precipitant injury, family history of epilepsy, disease duration, age of epilepsy onset, seizure frequency and presence of psychiatric axis-II diagnosis. The variance of QOLIE-31 sub-scales was: seizure worry=7%; overall QOL=11%; emotional well-being=32%; energy/fatigue=38%; cognitive function=13%; medication effects=7%; social function=13% (R coefficient between 0.30 and 0.65). SIGNIFICANCE: The pre-surgical variables studied had relatively low prediction capacity for the overall QOLIE-31 score and its sub-scales in this set of Brazilian patients with refractory MTLE-HS.
PURPOSE: The identification of variables associated with health-related quality of life (HRQoL) in patients with mesial temporal lobe epilepsy related to hippocampal sclerosis (MTLE-HS) would improve surgical decision-making and post-operatory follow-up in this group of patients. METHODS: We analyzed the independent association between the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) of 81 consecutive patients with refractory MTLE-HS. The clinical, demographic, radiological and electrophysiological variables were analyzed by multiple linear regression analysis. KEY FINDINGS: Approximately 36% (adjusted R(2)=0.36; R coefficient=0.66) of the QOLIE-31 overall score variance was explained by the history of initial precipitant injury, family history of epilepsy, disease duration, age of epilepsy onset, seizure frequency and presence of psychiatric axis-II diagnosis. The variance of QOLIE-31 sub-scales was: seizure worry=7%; overall QOL=11%; emotional well-being=32%; energy/fatigue=38%; cognitive function=13%; medication effects=7%; social function=13% (R coefficient between 0.30 and 0.65). SIGNIFICANCE: The pre-surgical variables studied had relatively low prediction capacity for the overall QOLIE-31 score and its sub-scales in this set of Brazilian patients with refractory MTLE-HS.
Authors: Rodrigo Bainy Leal; Mark William Lopes; Douglas Affonso Formolo; Cristiane Ribeiro de Carvalho; Alexandre Ademar Hoeller; Alexandra Latini; Daniel Santos Sousa; Peter Wolf; Rui Daniel Prediger; Zuner Assis Bortolotto; Marcelo Neves Linhares; Kátia Lin; Roger Walz Journal: Mol Psychiatry Date: 2018-06-07 Impact factor: 15.992
Authors: Marcelo Fernando Ronsoni; Aline Pertile Remor; Mark William Lopes; Alexandre Hohl; Iris H Z Troncoso; Rodrigo Bainy Leal; Gustavo Luchi Boos; Charles Kondageski; Jean Costa Nunes; Marcelo Neves Linhares; Kátia Lin; Alexandra Susana Latini; Roger Walz Journal: Neurochem Res Date: 2015-11-19 Impact factor: 3.996
Authors: M W Lopes; R B Leal; R Guarnieri; M L Schwarzbold; A Hoeller; A P Diaz; G L Boos; K Lin; M N Linhares; J C Nunes; J Quevedo; Z A Bortolotto; H J Markowitsch; S L Lightman; R Walz Journal: Transl Psychiatry Date: 2016-12-13 Impact factor: 6.222