Literature DB >> 23031715

EBNA1 and host factors in Epstein-Barr virus latent DNA replication.

Lori Frappier1.   

Abstract

Epstein-Barr virus episomes (EBV) replicate once per cell cycle during latent infection from the latent origin, oriP. This replication requires the viral EBNA1 protein, which specifically recognizes sequences in oriP and recruits cellular proteins to this origin. Replication from oriP requires the cellular origin recognition and MCM helicase complexes and also involves telomeric factors (including TRF2) that associate with repeated nonameric sequences at the origin. Replication from oriP occurs late in S-phase and this timing appears to be important for efficient replication. Replication from oriP has proven to be a valuable system for elucidating cellular proteins and mechanisms of origin activation.
Copyright © 2012 Elsevier B.V. All rights reserved.

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Year:  2012        PMID： 23031715     DOI： 10.1016/j.coviro.2012.09.005

Source DB:  PubMed          Journal:  Curr Opin Virol        ISSN： 1879-6257            Impact factor:   7.090


  29 in total

1.  Structural and Functional Basis for an EBNA1 Hexameric Ring in Epstein-Barr Virus Episome Maintenance.

Authors:  Julianna S Deakyne; Kimberly A Malecka; Troy E Messick; Paul M Lieberman
Journal:  J Virol       Date:  2017-09-12       Impact factor: 5.103

2.  Epstein-Barr virus EBNA1 protein regulates viral latency through effects on let-7 microRNA and dicer.

Authors:  Sheila Mansouri; Qun Pan; Benjamin J Blencowe; Julie M Claycomb; Lori Frappier
Journal:  J Virol       Date:  2014-07-16       Impact factor: 5.103

3.  Bacterial artificial chromosomes establish replication timing and sub-nuclear compartment de novo as extra-chromosomal vectors.

Authors:  Jiao Sima; Daniel A Bartlett; Molly R Gordon; David M Gilbert
Journal:  Nucleic Acids Res       Date:  2018-02-28       Impact factor: 16.971

4.  Structural Basis for Cooperative Binding of EBNA1 to the Epstein-Barr Virus Dyad Symmetry Minimal Origin of Replication.

Authors:  Kimberly A Malecka; Jayaraju Dheekollu; Julianna S Deakyne; Andreas Wiedmer; Ursula D Ramirez; Paul M Lieberman; Troy E Messick
Journal:  J Virol       Date:  2019-09-30       Impact factor: 5.103

5.  Opportunistic DNA Recombination With Epstein-Barr Virus at Sites of Control Region Rearrangements Mediating JC Virus Neurovirulence.

Authors:  Margaret J Wortman; Patric S Lundberg; Ayuna V Dagdanova; Pranav Venkataraman; Dianne C Daniel; Edward M Johnson
Journal:  J Infect Dis       Date:  2015-12-21       Impact factor: 5.226

6.  Ribosome Protein L4 is essential for Epstein-Barr Virus Nuclear Antigen 1 function.

Authors:  Chih-Lung Shen; Cheng-Der Liu; Ren-In You; Yung-Hao Ching; Jun Liang; Liangru Ke; Ya-Lin Chen; Hong-Chi Chen; Hao-Jen Hsu; Je-Wen Liou; Elliott Kieff; Chih-Wen Peng
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

7.  Crystal Structure of the DNA-Binding Domain of Human Herpesvirus 6A Immediate Early Protein 2.

Authors:  Mitsuhiro Nishimura; Junjie Wang; Aika Wakata; Kento Sakamoto; Yasuko Mori
Journal:  J Virol       Date:  2017-10-13       Impact factor: 5.103

8.  Identification of a novel protein interaction motif in the regulatory subunit of casein kinase 2.

Authors:  Jennifer Yinuo Cao; Kathy Shire; Cameron Landry; Gerald D Gish; Tony Pawson; Lori Frappier
Journal:  Mol Cell Biol       Date:  2013-11-11       Impact factor: 4.272

9.  Nucleolin is important for Epstein-Barr virus nuclear antigen 1-mediated episome binding, maintenance, and transcription.

Authors:  Ya-Lin Chen; Cheng-Der Liu; Chi-Ping Cheng; Bo Zhao; Hao-Jen Hsu; Chih-Long Shen; Shu-Jun Chiu; Elliott Kieff; Chih-wen Peng
Journal:  Proc Natl Acad Sci U S A       Date:  2013-12-16       Impact factor: 11.205

Review 10.  Epstein-Barr virus latency: current and future perspectives.

Authors:  Bettina Kempkes; Erle S Robertson
Journal:  Curr Opin Virol       Date:  2015-10       Impact factor: 7.090
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