Literature DB >> 23031597

Chemotherapy of leishmaniasis. Part XI: synthesis and bioevaluation of novel isoxazole containing heteroretinoid and its amide derivatives.

S N Suryawanshi1, Avinash Tiwari, Naveen Chandra, Suman Gupta.   

Abstract

Novel isoxazole containing heteroretinoid (4) and its amide derivatives (5a-j) have been synthesized and evaluated for their in vivo antileishmanial activity against Leishmania donovani in hamsters. Compounds 3, 5a, 5d, 5k and 5l inhibited 70-76% parasite growth at 50 mg kg(-1) ×5 days. The present study has helped us in identifying a new lead that could be exploited as a potential antileishmanial agent.
Copyright © 2012 Elsevier Ltd. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23031597     DOI： 10.1016/j.bmcl.2012.09.024

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  6 in total

1.  Novel Heteroaryl Selenocyanates and Diselenides as Potent Antileishmanial Agents.

Authors:  Ylenia Baquedano; Verónica Alcolea; Miguel Ángel Toro; Killian Jesús Gutiérrez; Paul Nguewa; María Font; Esther Moreno; Socorro Espuelas; Antonio Jiménez-Ruiz; Juan Antonio Palop; Daniel Plano; Carmen Sanmartín
Journal:  Antimicrob Agents Chemother       Date:  2016-05-23       Impact factor: 5.191

2.  Evaluation of Triazole and Isoxazole Derivatives as Potential Anti-infective Agents.

Authors:  Amer H Tarawneh; Lo Ay A Al-Momani; Francisco León; Surenda K Jain; Anastassiya V Gadetskaya; Sultan T Abu-Orabi; Babu L Tekwani; Stephen J Cutler
Journal:  Med Chem Res       Date:  2018-02-27       Impact factor: 1.965

3.  Magnetic sulfonated polysaccharides as efficient catalysts for synthesis of isoxazole-5-one derivatives possessing a substituted pyrrole ring, as anti-cancer agents.

Authors:  Zarrin Ghasemi; Afsaneh Hamidian Amale; Sajjad Azizi; Sepideh Valizadeh; Jafar Soleymani
Journal:  RSC Adv       Date:  2021-11-17       Impact factor: 3.361

4.  Antileishmanial assessment of isoxazole derivatives against L. donovani.

Authors:  Sushobhan Mukhopadhyay; Dinesh S Barak; R Karthik; Sarvesh K Verma; Rabi S Bhatta; Neena Goyal; Sanjay Batra
Journal:  RSC Med Chem       Date:  2020-07-20

5.  Crystal structure and Hirshfeld surface analysis of (Z)-4-(4-hy-droxy-benzyl-idene)-3-methyl-isoxazol-5(4H)-one.

Authors:  Wissem Zemamouche; Rima Laroun; Noudjoud Hamdouni; Ouarda Brihi; Ali Boudjada; Abdelmadjid Debache
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2018-06-08

6.  Synthesis and Antiprotozoal Profile of 3,4,5-Trisubstituted Isoxazoles.

Authors:  Fernanda Andreia Rosa; Samara Mendes de Souza Melo; Karlos Eduardo Pianoski; Julia Poletto; Mariellen Guilherme Dos Santos; Michael Jackson Vieira da Silva; Danielle Lazarin-Bidóia; Hélito Volpato; Sidnei Moura; Celso Vataru Nakamura
Journal:  ChemistryOpen       Date:  2021-07-30       Impact factor: 2.630
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.