| Literature DB >> 23031595 |
Yanhui Yang1, Andrew Voak, Shane R Wilkinson, Longqin Hu.
Abstract
A series of potential DFMO prodrugs was designed through the incorporation of 4-nitrobenzyl ester or carbamate groups for potential activation by trypanosomal nitroreductase. It was found that only modification of N(ε)-amino group of DFMO by 4-nitro-2-fluorobenzyloxycarbonyl resulted in significant trypanocidal activity and could serve as a lead for further investigation.Entities:
Mesh：
Substances：
Year: 2012 PMID： 23031595 DOI： 10.1016/j.bmcl.2012.09.005
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823