| Literature DB >> 23031591 |
Ash Bahl1, Patrick Barton, Keith Bowers, Steven Brough, Richard Evans, Christopher A Luckhurst, Tobias Mochel, Matthew W D Perry, Aaron Rigby, Robert J Riley, Hitesh Sanganee, Adam Sisson, Brian Springthorpe.
Abstract
A series of dual CCR3/H(1) antagonists based on a bispiperidine scaffold were discovered. Introduction of an acidic group overcame hERG liability. Bioavailability was optimised by modulation of physico-chemical properties and physical form to deliver a compound suitable for clinical evaluation.Entities:
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Year: 2012 PMID： 23031591 DOI： 10.1016/j.bmcl.2012.08.124
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823