| Literature DB >> 2303071 |
R Hampl1, L Foretová, J Sulcová, L Stárka.
Abstract
Daily profiles of salivary cortisol were determined in 14 cortisol-treated children with congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency, and in 5 healthy sibs. The results showed considerable individual variation irrespective of the dose of hormone, reflecting the different rates of cortisol metabolism and transport. Maximum salivary cortisol levels were reached 1-2 h following oral administration of hydrocortisone. The determination of salivary cortisol may be useful for optimal dosage timing, i.e. to imitate the daily rhythm of normal cortisol secretion.Entities:
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Year: 1990 PMID: 2303071 DOI: 10.1007/bf02106278
Source DB: PubMed Journal: Eur J Pediatr ISSN: 0340-6199 Impact factor: 3.183