Literature DB >> 23030067

The combined effect of persistent organic pollutants in the serum POP mixture in Greenlandic Inuit: xenoestrogenic, xenoandrogenic and dioxin-like transactivities.

Tanja Krüger1, Manhai Long, Mandana Ghisari, Eva C Bonefeld-Jørgensen.   

Abstract

Greenlandic Inuit have high body burden of persistent organic pollutants (POPs). We analyzed the combined effect of the actual lipophilic serum POP mixture on estrogen-, androgen- and aryl hydrocarbon-receptor functions as effect biomarkers, and the associations between the effect biomarkers and serum POPs, and lifestyle characteristics. The serum POPs were extracted from 232 Inuit from Ittoqqortoormiit, Narsaq and Qeqertarsuaq. The POP-related receptor transactivities correlated negatively to the POP levels and were associated to the lifestyle characteristics. The POP-related receptor transactivities can be used as effect biomarkers. The serum POPs have hormone disruptive potentials.

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Year:  2012        PMID： 23030067     DOI： 10.3109/1354750X.2012.700950

Source DB:  PubMed          Journal:  Biomarkers        ISSN： 1354-750X            Impact factor:   2.658


  7 in total

Review 1.  Biomonitoring and hormone-disrupting effect biomarkers of persistent organic pollutants in vitro and ex vivo.

Authors:  Eva C Bonefeld-Jørgensen; Mandana Ghisari; Maria Wielsøe; Christian Bjerregaard-Olesen; Lisbeth S Kjeldsen; Manhai Long
Journal:  Basic Clin Pharmacol Toxicol       Date:  2014-05-29       Impact factor: 4.080

2.  Health effects associated with measured levels of contaminants in the Arctic.

Authors:  Pál Weihe; Fróði Debes; Jónrit Halling; Maria Skaalum Petersen; Gina Muckle; Jon Øyvind Odland; Alexey Dudarev; Pierre Ayotte; Éric Dewailly; Philippe Grandjean; Eva Bonefeld-Jørgensen
Journal:  Int J Circumpolar Health       Date:  2016-12-13       Impact factor: 1.228

3.  Detection of aryl hydrocarbon receptor agonists in human samples.

Authors:  Veit Rothhammer; Davis M Borucki; Jessica E Kenison; Patrick Hewson; Zhongyan Wang; Rohit Bakshi; David H Sherr; Francisco J Quintana
Journal:  Sci Rep       Date:  2018-03-21       Impact factor: 4.379

Review 4.  Polychlorinated biphenyls (PCBs) as sentinels for the elucidation of Arctic environmental change processes: a comprehensive review combined with ArcRisk project results.

Authors:  Pernilla Carlsson; Knut Breivik; Eva Brorström-Lundén; Ian Cousins; Jesper Christensen; Joan O Grimalt; Crispin Halsall; Roland Kallenborn; Khaled Abass; Gerhard Lammel; John Munthe; Matthew MacLeod; Jon Øyvind Odland; Janet Pawlak; Arja Rautio; Lars-Otto Reiersen; Martin Schlabach; Irene Stemmler; Simon Wilson; Henry Wöhrnschimmel
Journal:  Environ Sci Pollut Res Int       Date:  2018-06-28       Impact factor: 4.223

5.  Prenatal exposure to persistent organic pollutants and metals and problematic child behavior at 3-5 years of age: a Greenlandic cohort study.

Authors:  Simon Kornvig; Maria Wielsøe; Manhai Long; Eva Cecilie Bonefeld-Jørgensen
Journal:  Sci Rep       Date:  2021-11-12       Impact factor: 4.379

6.  Dioxin-like Activity in Pregnant Women and Indices of Fetal Growth: The ACCEPT Birth Cohort.

Authors:  Manhai Long; Maria Wielsøe; Eva Cecilie Bonefeld-Jørgensen
Journal:  Toxics       Date:  2022-01-08

Review 7.  Association between environmental contaminants and health outcomes in indigenous populations of the Circumpolar North.

Authors:  Kavita Singh; Peter Bjerregaard; Hing Man Chan
Journal:  Int J Circumpolar Health       Date:  2014-12-05       Impact factor: 1.941
  7 in total

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