Literature DB >> 2302761

Formation of 8-hydroxydeoxyguanosine (8-OH-dG) in rat kidney DNA after intraperitoneal administration of ferric nitrilotriacetate (Fe-NTA).

T Umemura1, K Sai, A Takagi, R Hasegawa, Y Kurokawa.   

Abstract

A significant increase of 8-hydroxydeoxyguanosine (8-OH-dG) was observed in the kidney DNA of rats given a renal carcinogen, the ferric complex of nitrilotriacetate (Fe-NTA) by single i.p. injection. By contrast, non- or weakly carcinogenic compounds, aluminum-nitrilotriacetate complex (Al-NTA), non-complexed NTA (Na2NTA) and ferric chloride had no effect on 8-OH-dG production in the kidney DNA. These results suggest the involvement of active oxygen radicals in Fe-NTA carcinogenesis.

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Year:  1990        PMID： 2302761     DOI： 10.1093/carcin/11.2.345

Source DB:  PubMed          Journal:  Carcinogenesis        ISSN： 0143-3334            Impact factor:   4.944


  22 in total

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Review 2.  Iron toxicity and chelation therapy.

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3.  Oxidative DNA damage and cellular sensitivity to oxidative stress in human autoimmune diseases.

Authors:  S Bashir; G Harris; M A Denman; D R Blake; P G Winyard
Journal:  Ann Rheum Dis       Date:  1993-09       Impact factor: 19.103

4.  Nrf2 protects against As(III)-induced damage in mouse liver and bladder.

Authors:  Tao Jiang; Zheping Huang; Jefferson Y Chan; Donna D Zhang
Journal:  Toxicol Appl Pharmacol       Date:  2009-06-16       Impact factor: 4.219

5.  Formation of 4-hydroxy-2-nonenal-modified proteins in the renal proximal tubules of rats treated with a renal carcinogen, ferric nitrilotriacetate.

Authors:  S Toyokuni; K Uchida; K Okamoto; Y Hattori-Nakakuki; H Hiai; E R Stadtman
Journal:  Proc Natl Acad Sci U S A       Date:  1994-03-29       Impact factor: 11.205

6.  Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention.

Authors:  Mohammad Iqbal; Yasumasa Okazaki; Shigeru Okada
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Review 7.  Current aspects in metal genotoxicity.

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Journal:  Biometals       Date:  1995-01       Impact factor: 2.949

8.  Mechanism of oxidative DNA damage in diabetes: tuberin inactivation and downregulation of DNA repair enzyme 8-oxo-7,8-dihydro-2'-deoxyguanosine-DNA glycosylase.

Authors:  Simona Simone; Yves Gorin; Chakradhar Velagapudi; Hanna E Abboud; Samy L Habib
Journal:  Diabetes       Date:  2008-07-03       Impact factor: 9.461

9.  Increase in the 8-hydroxyguanine repair activity in the rat kidney after the administration of a renal carcinogen, ferric nitrilotriacetate.

Authors:  R Yamaguchi; T Hirano; S Asami; A Sugita; H Kasai
Journal:  Environ Health Perspect       Date:  1996-05       Impact factor: 9.031

10.  Active oxygen species in DNA damage induced by carcinogenic metal compounds.

Authors:  S Kawanishi; S Inoue; K Yamamoto
Journal:  Environ Health Perspect       Date:  1994-09       Impact factor: 9.031
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