Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Insight into DEG/ENaC channel gating from genetics and structure.

Literature DB >> 23026751

Insight into DEG/ENaC channel gating from genetics and structure.

Abstract

The founding members of the superfamily of DEG/ENaC ion channel proteins are C. elegans proteins that form mechanosensitive channels in touch and pain receptors. For more than a decade, the research community has used mutagenesis to identify motifs that regulate gating. This review integrates insight derived from unbiased in vivo mutagenesis screens with recent crystal structures to develop new models for activation of mechanically gated DEGs.

Entities: Chemical Disease Gene Mutation Species

Mesh：

Substances：

Year: 2012 PMID： 23026751 PMCID： PMC4012085 DOI： 10.1152/physiol.00006.2012

Source DB: PubMed Journal: Physiology (Bethesda) ISSN： 1548-9221

71 in total

1. The GxxxG motif: a framework for transmembrane helix-helix association.

Authors: W P Russ; D M Engelman
Journal: J Mol Biol Date: 2000-02-25 Impact factor: 5.469

2. Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channel.

Authors: Tianbo Li; Youshan Yang; Cecilia M Canessa
Journal: Am J Physiol Cell Physiol Date: 2010-04-28 Impact factor: 4.249

3. Leu85 in the beta1-beta2 linker of ASIC1 slows activation and decreases the apparent proton affinity by stabilizing a closed conformation.

Authors: Tianbo Li; Youshan Yang; Cecilia M Canessa
Journal: J Biol Chem Date: 2010-05-17 Impact factor: 5.157

4. Molecular mechanism of ATP binding and ion channel activation in P2X receptors.

Authors: Motoyuki Hattori; Eric Gouaux
Journal: Nature Date: 2012-05-10 Impact factor: 49.962

5. The DEG/ENaC protein MEC-10 regulates the transduction channel complex in Caenorhabditis elegans touch receptor neurons.

Authors: Jóhanna Arnadóttir; Robert O'Hagan; Yushu Chen; Miriam B Goodman; Martin Chalfie
Journal: J Neurosci Date: 2011-08-31 Impact factor: 6.167

Review 6. How we feel: ion channel partnerships that detect mechanical inputs and give rise to touch and pain perception.

Authors: Shana L Geffeney; Miriam B Goodman
Journal: Neuron Date: 2012-05-24 Impact factor: 17.173

7. In vivo structure-function analyses of Caenorhabditis elegans MEC-4, a candidate mechanosensory ion channel subunit.

Authors: K Hong; I Mano; M Driscoll
Journal: J Neurosci Date: 2000-04-01 Impact factor: 6.167

8. Characterization of the selectivity filter of the epithelial sodium channel.

Authors: S Sheng; J Li; K A McNulty; D Avery; T R Kleyman
Journal: J Biol Chem Date: 2000-03-24 Impact factor: 5.157

9. A mutation of the epithelial sodium channel associated with atypical cystic fibrosis increases channel open probability and reduces Na+ self inhibition.

Authors: Robert Rauh; Alexei Diakov; Anja Tzschoppe; Judit Korbmacher; Abul Kalam Azad; Harry Cuppens; Jean-Jaques Cassiman; Jörg Dötsch; Heinrich Sticht; Christoph Korbmacher
Journal: J Physiol Date: 2010-03-01 Impact factor: 5.182

10. Amiloride docking to acid-sensing ion channel-1.

Authors: Yawar J Qadri; Yuhua Song; Catherine M Fuller; Dale J Benos
Journal: J Biol Chem Date: 2010-01-04 Impact factor: 5.157

26 in total

Review 1. Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology.

Authors: Thomas M Suchyna
Journal: Prog Biophys Mol Biol Date: 2017-08-06 Impact factor: 3.667

2. Exploration of the Peptide Recognition of an Amiloride-sensitive FMRFamide Peptide-gated Sodium Channel.

Authors: You-Ya Niu; Yang Yang; Yan Liu; Li-Dong Huang; Xiao-Na Yang; Ying-Zhe Fan; Xiao-Yang Cheng; Peng Cao; You-Min Hu; Lingyong Li; Xiang-Yang Lu; Yun Tian; Ye Yu
Journal: J Biol Chem Date: 2016-02-11 Impact factor: 5.157

3. Gamma subunit second transmembrane domain contributes to epithelial sodium channel gating and amiloride block.

Authors: Shujie Shi; Thomas R Kleyman
Journal: Am J Physiol Renal Physiol Date: 2013-10-09

4. The Drosophila Postsynaptic DEG/ENaC Channel ppk29 Contributes to Excitatory Neurotransmission.

Authors: Alexis Hill; Xingguo Zheng; Xiling Li; Ross McKinney; Dion Dickman; Yehuda Ben-Shahar
Journal: J Neurosci Date: 2017-02-17 Impact factor: 6.167

5. A method for activation of endogenous acid-sensing ion channel 1a (ASIC1a) in the nervous system with high spatial and temporal precision.

Authors: Tianbo Li; Youshan Yang; Cecilia M Canessa
Journal: J Biol Chem Date: 2014-04-11 Impact factor: 5.157

6. The nonproton ligand of acid-sensing ion channel 3 activates mollusk-specific FaNaC channels via a mechanism independent of the native FMRFamide peptide.

Authors: Xiao-Na Yang; You-Ya Niu; Yan Liu; Yang Yang; Jin Wang; Xiao-Yang Cheng; Hong Liang; Heng-Shan Wang; You-Min Hu; Xiang-Yang Lu; Michael X Zhu; Tian-Le Xu; Yun Tian; Ye Yu
Journal: J Biol Chem Date: 2017-11-09 Impact factor: 5.157

7. Analyses of epithelial Na⁺ channel variants reveal that an extracellular β-ball domain critically regulates ENaC gating.

Authors: Xueqi Wang; Jingxin Chen; Shujie Shi; Shaohu Sheng; Thomas R Kleyman
Journal: J Biol Chem Date: 2019-09-24 Impact factor: 5.157

Review 8. Carbon monoxide--physiology, detection and controlled release.

Authors: Stefan H Heinemann; Toshinori Hoshi; Matthias Westerhausen; Alexander Schiller
Journal: Chem Commun (Camb) Date: 2014-04-11 Impact factor: 6.222

9. Activation of the Caenorhabditis elegans Degenerin Channel by Shear Stress Requires the MEC-10 Subunit.

Authors: Shujie Shi; Cliff J Luke; Mark T Miedel; Gary A Silverman; Thomas R Kleyman
Journal: J Biol Chem Date: 2016-05-04 Impact factor: 5.157

Review 10. Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.

Authors: Israel Hanukoglu; Aaron Hanukoglu
Journal: Gene Date: 2016-01-07 Impact factor: 3.688