Literature DB >> 23025824

Inhibition of Acyl-CoA: cholesterol acyltransferase (ACAT), overexpression of cholesterol transporter gene, and protection of amyloid β (Aβ) oligomers-induced neuronal cell death by tricyclic pyrone molecules.

Laxman Pokhrel1, Izumi Maezawa, Thi D T Nguyen, Kyeong-Ok Chang, Lee-Way Jin, Duy H Hua.   

Abstract

A major effort in Alzheimer's disease therapeutic development has targeted Aβ and downstream events. We have synthesized a small library of tricyclic pyrone compounds. Their protective action in MC65 cells and inhibition of ACAT along with the upregulation of cholesterol transporter gene were investigated. Five active compounds exhibited potencies in the nanomolar ranges. The multiple effects of the compounds on Aβ and cellular cholesterol pathways could be potential mechanisms underlying the protective effects in vivo.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 23025824      PMCID： PMC3486708          DOI： 10.1021/jm3012189

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  26 in total

Review 1.  Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease.

Authors:  Robert W Mahley; Karl H Weisgraber; Yadong Huang
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-27       Impact factor: 11.205

2.  Induction of the cholesterol transporter ABCA1 in central nervous system cells by liver X receptor agonists increases secreted Abeta levels.

Authors:  Hiroaki Fukumoto; Amy Deng; Michael C Irizarry; Michael L Fitzgerald; G William Rebeck
Journal:  J Biol Chem       Date:  2002-10-15       Impact factor: 5.157

3.  A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis.

Authors:  A Chawla; W A Boisvert; C H Lee; B A Laffitte; Y Barak; S B Joseph; D Liao; L Nagy; P A Edwards; L K Curtiss; R M Evans; P Tontonoz
Journal:  Mol Cell       Date:  2001-01       Impact factor: 17.970

4.  Iodine(V) reagents in organic synthesis. Part 4. o-Iodoxybenzoic acid as a chemospecific tool for single electron transfer-based oxidation processes.

Authors:  K C Nicolaou; T Montagnon; P S Baran; Y-L Zhong
Journal:  J Am Chem Soc       Date:  2002-03-13       Impact factor: 15.419

5.  Inhibition of Alzheimer's amyloid toxicity with a tricyclic pyrone molecule in vitro and in vivo.

Authors:  Hyun-Seok Hong; Sandeep Rana; Lydia Barrigan; Aibin Shi; Yi Zhang; Feimeng Zhou; Lee-Way Jin; Duy H Hua
Journal:  J Neurochem       Date:  2009-02       Impact factor: 5.372

6.  Comparison of CI-976, an ACAT inhibitor, and selected lipid-lowering agents for antiatherosclerotic activity in iliac-femoral and thoracic aortic lesions. A biochemical, morphological, and morphometric evaluation.

Authors:  T M Bocan; S B Mueller; P D Uhlendorf; R S Newton; B R Krause
Journal:  Arterioscler Thromb       Date:  1991 Nov-Dec

7.  Impact of 27-hydroxycholesterol on amyloid-beta peptide production and ATP-binding cassette transporter expression in primary human neurons.

Authors:  Woojin Scott Kim; Sharon L Chan; Andrew F Hill; Gilles J Guillemin; Brett Garner
Journal:  J Alzheimers Dis       Date:  2009       Impact factor: 4.472

Review 8.  Alzheimer's disease: the cholesterol connection.

Authors:  Luigi Puglielli; Rudolph E Tanzi; Dora M Kovacs
Journal:  Nat Neurosci       Date:  2003-04       Impact factor: 24.884

9.  Alzheimer's disease and the amyloid cascade hypothesis: a critical review.

Authors:  Christiane Reitz
Journal:  Int J Alzheimers Dis       Date:  2012-03-17

10.  Tricyclic pyrone compounds prevent aggregation and reverse cellular phenotypes caused by expression of mutant huntingtin protein in striatal neurons.

Authors:  Eugenia Trushina; Sandeep Rana; Cynthia T McMurray; Duy H Hua
Journal:  BMC Neurosci       Date:  2009-07-08       Impact factor: 3.288
View more
  7 in total

1.  ATR-101 inhibits cholesterol efflux and cortisol secretion by ATP-binding cassette transporters, causing cytotoxic cholesterol accumulation in adrenocortical carcinoma cells.

Authors:  Veronica Elizabeth Burns; Tom Klaus Kerppola
Journal:  Br J Pharmacol       Date:  2017-08-30       Impact factor: 8.739

2.  Syntheses, neural protective activities, and inhibition of glycogen synthase kinase-3β of substituted quinolines.

Authors:  Jianyu Lu; Izumi Maezawa; Sahani Weerasekara; Ramazan Erenler; Tuyen D T Nguyen; James Nguyen; Luxi Z Swisher; Jun Li; Lee-Way Jin; Alok Ranjan; Sanjay K Srivastava; Duy H Hua
Journal:  Bioorg Med Chem Lett       Date:  2014-06-04       Impact factor: 2.823

3.  Syntheses of 3-[(Alkylamino)methylene]-6-methylpyridine-2,4(1H,3H)-diones, 3-Substituted 7-Methyl-2H-pyrano[3,2-c]pyridine-2,5(6H)-dione Fluorescence Probes, and Tetrahydro-1H,9H-2,10-dioxa-9-azaanthracen-1-ones.

Authors:  Allan M Prior; Medha J Gunaratna; Daisuke Kikuchi; John Desper; Yunjeong Kim; Kyeong-Ok Chang; Izumi Maezawa; Lee-Way Jin; Duy H Hua
Journal:  Synthesis (Stuttg)       Date:  2014-08       Impact factor: 3.157

4.  Modulation of mitochondrial complex I activity averts cognitive decline in multiple animal models of familial Alzheimer's Disease.

Authors:  Liang Zhang; Song Zhang; Izumi Maezawa; Sergey Trushin; Paras Minhas; Matthew Pinto; Lee-Way Jin; Keshar Prasain; Thi D T Nguyen; Yu Yamazaki; Takahisa Kanekiyo; Guojun Bu; Benjamin Gateno; Kyeong-Ok Chang; Karl A Nath; Emirhan Nemutlu; Petras Dzeja; Yuan-Ping Pang; Duy H Hua; Eugenia Trushina
Journal:  EBioMedicine       Date:  2015-04-01       Impact factor: 8.143

5.  The Anti-Amyloid-β and Neuroprotective Properties of a Novel Tricyclic Pyrone Molecule.

Authors:  Izumi Maezawa; Bende Zou; Jacopo Di Lucente; William S Cao; Conrado Pascual; Sahani Weerasekara; Man Zhang; Xinmin Simon Xie; Duy H Hua; Lee-Way Jin
Journal:  J Alzheimers Dis       Date:  2017       Impact factor: 4.472

6.  Eco-friendly synthesis of fused pyrano[2,3-b]pyrans via ammonium acetate-mediated formal oxa-[3 + 3]cycloaddition of 4H-chromene-3-carbaldehydes and cyclic 1,3-dicarbonyl compounds.

Authors:  Vitaly A Osyanin; Dmitry V Osipov; Irina A Semenova; Kirill S Korzhenko; A V Lukashenko; Oleg P Demidov; Yuri N Klimochkin
Journal:  RSC Adv       Date:  2020-09-16       Impact factor: 4.036

7.  Design, synthesis, and evaluation of bioactive small molecules.

Authors:  Duy H Hua
Journal:  Chem Rec       Date:  2012-12-20       Impact factor: 6.771
  7 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.