Literature DB >> 23025533

Common variants within 6p21.31 locus are associated with chronic lymphocytic leukaemia and, potentially, other non-Hodgkin lymphoma subtypes.

Susan L Slager1, Nicola J Camp, Lucia Conde, Tait D Shanafelt, Sara J Achenbach, Kari G Rabe, Neil E Kay, Anne J Novak, Timothy G Call, Paige M Bracci, Fenna M C Sille, Sylvia Sanchez, Nicholas K Akers, Julie M Cunningham, Daniel J Serie, Shannon K McDonnell, Jose F Leis, Alice H Wang, J Brice Weinberg, Martha Glenn, Brian Link, Celine M Vachon, Mark C Lanasa, Christine F Skibola, James R Cerhan.   

Abstract

A recent meta-analysis of three genome-wide association studies of chronic lymphocytic leukaemia (CLL) identified two common variants at the 6p21.31 locus that are associated with CLL risk. To verify and further explore the association of these variants with other non-Hodgkin lymphoma (NHL) subtypes, we genotyped 1196 CLL cases, 1699 NHL cases, and 2410 controls. We found significant associations between the 6p21.31 variants and CLL risk (rs210134: P = 0·01; rs210142: P = 6·8 × 10(-3)). These variants also showed a trend towards association with some of the other NHL subtypes. Our results validate the prior work and support specific genetic pathways for risk among NHL subtypes.
© 2012 Blackwell Publishing Ltd.

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Year:  2012        PMID： 23025533      PMCID： PMC3614403          DOI： 10.1111/bjh.12070

Source DB:  PubMed          Journal:  Br J Haematol        ISSN： 0007-1048            Impact factor:   6.998


  8 in total

1.  Quantifying heterogeneity in a meta-analysis.

Authors:  Julian P T Higgins; Simon G Thompson
Journal:  Stat Med       Date:  2002-06-15       Impact factor: 2.373

2.  Common variation at 6p21.31 (BAK1) influences the risk of chronic lymphocytic leukemia.

Authors:  Susan L Slager; Christine F Skibola; Maria Chiara Di Bernardo; Lucia Conde; Peter Broderick; Shannon K McDonnell; Lynn R Goldin; Naomi Croft; Amy Holroyd; Shelley Harris; Jacques Riby; Daniel J Serie; Neil E Kay; Timothy G Call; Paige M Bracci; Eran Halperin; Mark C Lanasa; Julie M Cunningham; Jose F Leis; Vicki A Morrison; Logan G Spector; Celine M Vachon; Tait D Shanafelt; Sara S Strom; Nicola J Camp; J Brice Weinberg; Estella Matutes; Neil E Caporaso; Rachel Wade; Martin J S Dyer; Claire Dearden; James R Cerhan; Daniel Catovsky; Richard S Houlston
Journal:  Blood       Date:  2012-06-13       Impact factor: 22.113

3.  The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data.

Authors:  Aaron McKenna; Matthew Hanna; Eric Banks; Andrey Sivachenko; Kristian Cibulskis; Andrew Kernytsky; Kiran Garimella; David Altshuler; Stacey Gabriel; Mark Daly; Mark A DePristo
Journal:  Genome Res       Date:  2010-07-19       Impact factor: 9.043

4.  Predicting the effects of coding non-synonymous variants on protein function using the SIFT algorithm.

Authors:  Prateek Kumar; Steven Henikoff; Pauline C Ng
Journal:  Nat Protoc       Date:  2009-06-25       Impact factor: 13.491

5.  Genome-wide association study identifies a novel susceptibility locus at 6p21.3 among familial CLL.

Authors:  Susan L Slager; Kari G Rabe; Sara J Achenbach; Celine M Vachon; Lynn R Goldin; Sara S Strom; Mark C Lanasa; Logan G Spector; Laura Z Rassenti; Jose F Leis; Nicola J Camp; Martha Glenn; Neil E Kay; Julie M Cunningham; Curtis A Hanson; Gerald E Marti; J Brice Weinberg; Vicki A Morrison; Brian K Link; Timothy G Call; Neil E Caporaso; James R Cerhan
Journal:  Blood       Date:  2010-12-03       Impact factor: 22.113

6.  Genetic association analysis highlights new loci that modulate hematological trait variation in Caucasians and African Americans.

Authors:  Ken Sin Lo; James G Wilson; Leslie A Lange; Aaron R Folsom; Geneviève Galarneau; Santhi K Ganesh; Struan F A Grant; Brendan J Keating; Steven A McCarroll; Emile R Mohler; Christopher J O'Donnell; Walter Palmas; Weihong Tang; Russell P Tracy; Alexander P Reiner; Guillaume Lettre
Journal:  Hum Genet       Date:  2010-12-12       Impact factor: 4.132

7.  A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

Authors:  Nicole Soranzo; Tim D Spector; Massimo Mangino; Brigitte Kühnel; Augusto Rendon; Alexander Teumer; Christina Willenborg; Benjamin Wright; Li Chen; Mingyao Li; Perttu Salo; Benjamin F Voight; Philippa Burns; Roman A Laskowski; Yali Xue; Stephan Menzel; David Altshuler; John R Bradley; Suzannah Bumpstead; Mary-Susan Burnett; Joseph Devaney; Angela Döring; Roberto Elosua; Stephen E Epstein; Wendy Erber; Mario Falchi; Stephen F Garner; Mohammed J R Ghori; Alison H Goodall; Rhian Gwilliam; Hakon H Hakonarson; Alistair S Hall; Naomi Hammond; Christian Hengstenberg; Thomas Illig; Inke R König; Christopher W Knouff; Ruth McPherson; Olle Melander; Vincent Mooser; Matthias Nauck; Markku S Nieminen; Christopher J O'Donnell; Leena Peltonen; Simon C Potter; Holger Prokisch; Daniel J Rader; Catherine M Rice; Robert Roberts; Veikko Salomaa; Jennifer Sambrook; Stefan Schreiber; Heribert Schunkert; Stephen M Schwartz; Jovana Serbanovic-Canic; Juha Sinisalo; David S Siscovick; Klaus Stark; Ida Surakka; Jonathan Stephens; John R Thompson; Uwe Völker; Henry Völzke; Nicholas A Watkins; George A Wells; H-Erich Wichmann; David A Van Heel; Chris Tyler-Smith; Swee Lay Thein; Sekar Kathiresan; Markus Perola; Muredach P Reilly; Alexandre F R Stewart; Jeanette Erdmann; Nilesh J Samani; Christa Meisinger; Andreas Greinacher; Panos Deloukas; Willem H Ouwehand; Christian Gieger
Journal:  Nat Genet       Date:  2009-10-11       Impact factor: 38.330

8.  A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.

Authors:  Rehan Qayyum; Beverly M Snively; Elad Ziv; Michael A Nalls; Yongmei Liu; Weihong Tang; Lisa R Yanek; Leslie Lange; Michele K Evans; Santhi Ganesh; Melissa A Austin; Guillaume Lettre; Diane M Becker; Alan B Zonderman; Andrew B Singleton; Tamara B Harris; Emile R Mohler; Benjamin A Logsdon; Charles Kooperberg; Aaron R Folsom; James G Wilson; Lewis C Becker; Alexander P Reiner
Journal:  PLoS Genet       Date:  2012-03-08       Impact factor: 5.917
  8 in total
  7 in total

1.  Fine-mapping of HLA associations with chronic lymphocytic leukemia in US populations.

Authors:  Loren Gragert; Stephanie Fingerson; Mark Albrecht; Martin Maiers; Matt Kalaycio; Brian T Hill
Journal:  Blood       Date:  2014-09-17       Impact factor: 22.113

2.  The association between HLA and non-Hodgkin lymphoma subtypes, among a transplant-indicated population.

Authors:  Charlie Zhong; Loren Gragert; Martin Maiers; Brian T Hill; Jean Garcia-Gomez; Ketevan Gendzekhadze; David Senitzer; Joo Song; Dennis Weisenburger; Leanne Goldstein; Sophia S Wang
Journal:  Leuk Lymphoma       Date:  2019-06-19

Review 3.  Etiology of Waldenström macroglobulinemia: genetic factors and immune-related conditions.

Authors:  Elisabet E Manasanch; Sigurdur Y Kristinsson; Ola Landgren
Journal:  Clin Lymphoma Myeloma Leuk       Date:  2013-03-07

Review 4.  Genetic susceptibility to chronic lymphocytic leukemia.

Authors:  Susan L Slager; Neil E Caporaso; Silvia de Sanjose; Lynn R Goldin
Journal:  Semin Hematol       Date:  2013-10       Impact factor: 3.851

5.  Trends in Disease Burden of Chronic Lymphocytic Leukemia at the Global, Regional, and National Levels From 1990 to 2019, and Projections Until 2030: A Population-Based Epidemiologic Study.

Authors:  Yang Ou; Yichen Long; Lili Ji; Yanxia Zhan; Tiankui Qiao; Xiangdong Wang; Hao Chen; Yunfeng Cheng
Journal:  Front Oncol       Date:  2022-03-10       Impact factor: 6.244

6.  Genome-Wide Association Analyses Identify Variants in IRF4 Associated With Acute Myeloid Leukemia and Myelodysplastic Syndrome Susceptibility.

Authors:  Junke Wang; Alyssa I Clay-Gilmour; Ezgi Karaesmen; Abbas Rizvi; Qianqian Zhu; Li Yan; Leah Preus; Song Liu; Yiwen Wang; Elizabeth Griffiths; Daniel O Stram; Loreall Pooler; Xin Sheng; Christopher Haiman; David Van Den Berg; Amy Webb; Guy Brock; Stephen Spellman; Marcelo Pasquini; Philip McCarthy; James Allan; Friedrich Stölzel; Kenan Onel; Theresa Hahn; Lara E Sucheston-Campbell
Journal:  Front Genet       Date:  2021-06-17       Impact factor: 4.599

7.  Pleiotropy of cancer susceptibility variants on the risk of non-Hodgkin lymphoma: the PAGE consortium.

Authors:  Unhee Lim; Jonathan M Kocarnik; William S Bush; Tara C Matise; Christian Caberto; Sungshim Lani Park; Christopher S Carlson; Ewa Deelman; David Duggan; Megan Fesinmeyer; Christopher A Haiman; Brian E Henderson; Lucia A Hindorff; Laurence N Kolonel; Ulrike Peters; Daniel O Stram; Maarit Tiirikainen; Lynne R Wilkens; Chunyuan Wu; Charles Kooperberg; Loïc Le Marchand
Journal:  PLoS One       Date:  2014-03-05       Impact factor: 3.240
  7 in total

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