Literature DB >> 23024482

A Case of Light Chain Deposition Disease (LCDD) in a Young Patient.

Mala Mahto1, Sudhesna Mohapatra, G Sumitra, Smita Kaushik, T K Mishra, Alpana Saxena.   

Abstract

Light chain disease is a variant of multiple myeloma in which the malignant population of marrow cells produces free monoclonal light chains but no heavy chain or complete immunoglobulin. The monoclonal light chains are small enough to be freely filtered by the kidneys and become Bence-Jones protein. Light chain disease comprises about 18% of multiple myeloma patients. Here we present a case report of a 38-year-old man who initially presented with complaints of pain in back and low grade fever off and on. He was found to have collapse of D9 and D12 vertebrae along with ascites and right pleural effusion and massive proteinuria. Multiple myeloma was considered as a differential diagnosis based on the investigations but eventually the patient was lost to follow up. This case is reported here as the light chain variant of multiple myeloma leading to deposition disease is less commonly reported and presents considerable difficulties in diagnosis.

Entities:  

Keywords:  Bence–Jones protein; Light chain disease; Multiple myeloma

Year:  2011        PMID: 23024482      PMCID: PMC3210242          DOI: 10.1007/s12291-010-0105-z

Source DB:  PubMed          Journal:  Indian J Clin Biochem        ISSN: 0970-1915


  3 in total

Review 1.  Multiple myeloma.

Authors:  Stephen M Korbet; Melvin M Schwartz
Journal:  J Am Soc Nephrol       Date:  2006-08-02       Impact factor: 10.121

2.  Correlation of abnormal immunoglobulin with clinical features of myeloma.

Authors: 
Journal:  Arch Intern Med       Date:  1975-01

3.  Light chain deposition disease presenting as paroxysmal atrial fibrillation: a case report.

Authors:  Fabio Fabbian; Nevio Stabellini; Sergio Sartori; Paola Tombesi; Arrigo Aleotti; Maurizio Bergami; Simona Uggeri; Adriana Galdi; Christian Molino; Luigi Catizone
Journal:  J Med Case Rep       Date:  2007-12-29
  3 in total
  1 in total

1.  IgG Lambda Myeloma Presenting as Plasmacytic Ascites: Case Report and Review of Literature.

Authors:  Subhashis Mitra; Sanghamitra Mukherjee; Hema Chakraborty; Maitreyee Bhattacharyya
Journal:  Indian J Hematol Blood Transfus       Date:  2014-09-03       Impact factor: 0.900

  1 in total

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