PURPOSE: To evaluate the efficiency and reproducibility of the extended FitzHugh & Nagumo (FHN) reaction-diffusion model proposed in this study for white matter hyperintensities (WMH) segmentation. MATERIALS AND METHODS: Five types of magnetic resonance T2-weighted fluid-attenuated inversion-recovery (T2FLAIR) images of 127 patients with different scanning parameters from five clinical scanner systems were selected for this study. After skull and scalp removal and denoise, the T2FLAIR images were processed by the proposed extended FHN model to obtain WMH. This new technique replaced the global threshold constant with a local threshold matrix. RESULTS: There was no significant difference between the segmentation results of the training set and the manual contouring against those between the test set and the manual contouring based on similarity index (SI) values (P = 0.5217). The SI values of the five types of T2FLAIR images were 86.0% ± 15.4%, 85.8% ± 10.5%, 84.1% ± 14.8%, 87.2% ± 14.6%, 86.3% ± 12.7%, respectively, comparing the segmentation results using the proposed method to the manual delineations. The overall SI value of the images was 86.5% ± 14.5%. This approach also demonstrated a better WMH segmentation performance over its classic form (P < 0.001). CONCLUSION: The proposed approach is efficient and could provide a more effective and convenient tool for clinical quantitative WMH analysis.
PURPOSE: To evaluate the efficiency and reproducibility of the extended FitzHugh & Nagumo (FHN) reaction-diffusion model proposed in this study for white matter hyperintensities (WMH) segmentation. MATERIALS AND METHODS: Five types of magnetic resonance T2-weighted fluid-attenuated inversion-recovery (T2FLAIR) images of 127 patients with different scanning parameters from five clinical scanner systems were selected for this study. After skull and scalp removal and denoise, the T2FLAIR images were processed by the proposed extended FHN model to obtain WMH. This new technique replaced the global threshold constant with a local threshold matrix. RESULTS: There was no significant difference between the segmentation results of the training set and the manual contouring against those between the test set and the manual contouring based on similarity index (SI) values (P = 0.5217). The SI values of the five types of T2FLAIR images were 86.0% ± 15.4%, 85.8% ± 10.5%, 84.1% ± 14.8%, 87.2% ± 14.6%, 86.3% ± 12.7%, respectively, comparing the segmentation results using the proposed method to the manual delineations. The overall SI value of the images was 86.5% ± 14.5%. This approach also demonstrated a better WMH segmentation performance over its classic form (P < 0.001). CONCLUSION: The proposed approach is efficient and could provide a more effective and convenient tool for clinical quantitative WMH analysis.
Authors: Leon Lenchik; Laura Heacock; Ashley A Weaver; Robert D Boutin; Tessa S Cook; Jason Itri; Christopher G Filippi; Rao P Gullapalli; James Lee; Marianna Zagurovskaya; Tara Retson; Kendra Godwin; Joey Nicholson; Ponnada A Narayana Journal: Acad Radiol Date: 2019-08-10 Impact factor: 3.173
Authors: Byung Il Yoo; Jung Jae Lee; Ji Won Han; San Yeo Wool Oh; Eun Young Lee; James R MacFall; Martha E Payne; Tae Hui Kim; Jae Hyoung Kim; Ki Woong Kim Journal: Neuroradiology Date: 2014-02-04 Impact factor: 2.804
Authors: Maria Eugenia Caligiuri; Paolo Perrotta; Antonio Augimeri; Federico Rocca; Aldo Quattrone; Andrea Cherubini Journal: Neuroinformatics Date: 2015-07