INTRODUCTION: Consumption of omega-3 fatty acids can alter the inflammatory response in diabetic patients. This study aimed to determine the effects of omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin (IL)-2 and tumour necrosis factor-alpha (TNF-α) in type 2 diabetes mellitus patients. METHODS: A randomised, double-blind, placebo-controlled clinical trial was conducted on 84 subjects aged 45-85 years with at least a two-year history of type 2 diabetes mellitus. Participants were randomly assigned to the treatment or control group. Each subject in the treatment group received three omega-3 capsules per day (eicosapentaenoic acid 1,548 mg; docosahexaenoic acid 828 mg; other omega-3 fatty acids 338 mg), while each subject in the control group received three placebo capsules (sunflower oil 2,100 mg) for a period of eight weeks. At the beginning of the study and post intervention, fasting blood samples were taken and serum concentrations of IL-2, TNF-α and CRP were assessed and compared. RESULTS:Serum IL-2 and TNF-α levels were significantly reduced in the treatment group compared to the controls (p < 0.01). There was no significant change in serum CRP levels. CONCLUSION:Short-term omega-3 fatty acid supplementation (3 g/day for eight weeks) can decrease the serum levels of TNF-α and IL-2 in diabetic patients, with no change in CRP levels. Consumption of omega-3 fatty acid supplements is highly recommended to alleviate inflammation caused by type 2 diabetes mellitus.
RCT Entities:
INTRODUCTION: Consumption of omega-3 fatty acids can alter the inflammatory response in diabeticpatients. This study aimed to determine the effects of omega-3 fatty acid supplementation on the serum levels of C-reactive protein (CRP), interleukin (IL)-2 and tumour necrosis factor-alpha (TNF-α) in type 2 diabetes mellituspatients. METHODS: A randomised, double-blind, placebo-controlled clinical trial was conducted on 84 subjects aged 45-85 years with at least a two-year history of type 2 diabetes mellitus. Participants were randomly assigned to the treatment or control group. Each subject in the treatment group received three omega-3 capsules per day (eicosapentaenoic acid 1,548 mg; docosahexaenoic acid 828 mg; other omega-3 fatty acids 338 mg), while each subject in the control group received three placebo capsules (sunflower oil 2,100 mg) for a period of eight weeks. At the beginning of the study and post intervention, fasting blood samples were taken and serum concentrations of IL-2, TNF-α and CRP were assessed and compared. RESULTS: Serum IL-2 and TNF-α levels were significantly reduced in the treatment group compared to the controls (p < 0.01). There was no significant change in serum CRP levels. CONCLUSION: Short-term omega-3 fatty acid supplementation (3 g/day for eight weeks) can decrease the serum levels of TNF-α and IL-2 in diabeticpatients, with no change in CRP levels. Consumption of omega-3 fatty acid supplements is highly recommended to alleviate inflammation caused by type 2 diabetes mellitus.
Authors: Theodore M Brasky; Todd R Sponholtz; Julie R Palmer; Lynn Rosenberg; Edward A Ruiz-Narváez; Lauren A Wise Journal: Am J Epidemiol Date: 2016-01-10 Impact factor: 4.897
Authors: Jessica L Krok-Schoen; Theodore M Brasky; Rebecca P Hunt; Thomas E Rohan; Tamara A Baker; Wenjun Li; Laura Carbone; Rachel H Mackey; Linda Snetselaar; Maryam B Lustberg; Marian L Neuhouser Journal: J Acad Nutr Diet Date: 2018-06-18 Impact factor: 4.910
Authors: Theodore M Brasky; Rebecca J Rodabough; Jingmin Liu; Michelle L Kurta; Lauren A Wise; Tonya S Orchard; David E Cohn; Martha A Belury; Emily White; JoAnn E Manson; Marian L Neuhouser Journal: Am J Clin Nutr Date: 2015-03-04 Impact factor: 7.045
Authors: Alison B Evert; Jackie L Boucher; Marjorie Cypress; Stephanie A Dunbar; Marion J Franz; Elizabeth J Mayer-Davis; Joshua J Neumiller; Robin Nwankwo; Cassandra L Verdi; Patti Urbanski; William S Yancy Journal: Diabetes Care Date: 2013-10-09 Impact factor: 19.112
Authors: Ning Lin; Jiao-Jiao Shi; Yun-Ming Li; Xin-Yan Zhang; Yi Chen; Philip C Calder; Li-Jun Tang Journal: Lipids Health Dis Date: 2016-08-20 Impact factor: 3.876