OBJECTIVE: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. RESULTS: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006-0.355). CONCLUSION: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis.
OBJECTIVE: Both adaptive and innate immune systems are involved in coronary artery disease (CAD). The aim of this study was to evaluate TH17 cytokines expression profiles in un-stimulated peripheral blood lymphocytes (PBMCs) of patients with coronary artery disease. METHODS: Expression profiles of IL-17, IL-23, and TGF-β1 were determined in individuals with and without CAD using Real-time PCR. RESULTS: A significant decrease in IL-23 gene expression in un-stimulated PBMCs of patients with CAD compared to those without CAD was found (p=0.003, OR=0.045, 95% CI: 0.006-0.355). CONCLUSION: Our data reinforce the potential role of the IL-23 as a critical regulatory molecule that bridges the innate and adaptive arms of the immune system in the complex mechanisms associated with the development of atherosclerosis.
Authors: M Karakose; K Demircan; E Tutal; T Demirci; M S Arslan; M Sahin; H T Celik; F Kazanci; J Karakaya; E Cakal; T Delibasi Journal: J Endocrinol Invest Date: 2016-05-04 Impact factor: 4.256
Authors: Aliia R Fatkhullina; Iuliia O Peshkova; Amiran Dzutsev; Turan Aghayev; John A McCulloch; Vishal Thovarai; Jonathan H Badger; Ravi Vats; Prithu Sundd; Hsin-Yao Tang; Andrew V Kossenkov; Stanley L Hazen; Giorgio Trinchieri; Sergei I Grivennikov; Ekaterina K Koltsova Journal: Immunity Date: 2018-10-30 Impact factor: 31.745
Authors: José Francisco Zambrano-Zaragoza; Enrique Jhonatan Romo-Martínez; Ma de Jesús Durán-Avelar; Noemí García-Magallanes; Norberto Vibanco-Pérez Journal: Int J Inflam Date: 2014-08-03
Authors: Katarzyna Fischer; Hanna Przepiera-Będzak; Marcin Sawicki; Anna Walecka; Iwona Brzosko; Marek Brzosko Journal: Mediators Inflamm Date: 2017-12-21 Impact factor: 4.711