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Literature DB >> 23022557

Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes.

Abstract

PARP enzymes influence the immune system at several key points and thus modulate inflammatory diseases. PARP enzymes affect immune cell maturation and differentiation and regulate the expression of inflammatory mediators such as cytokines, chemokines, inducible nitric oxide synthase and adhesion molecules. Moreover, PARP enzymes are key regulators of cell death during inflammation-related oxidative and nitrosative stress. Here we provide an overview of the different inflammatory diseases regulated by PARP enzymes.

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Year: 2012 PMID： 23022557 DOI： 10.1016/j.febslet.2012.09.026

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

40 in total

1. The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury.

Authors: Akbar Ahmad; Gabor Olah; David N Herndon; Csaba Szabo
Journal: Br J Pharmacol Date: 2017-03-05 Impact factor: 8.739

2. CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer.

Authors: Tomoe Higuchi; Dallas B Flies; Nicole A Marjon; Gina Mantia-Smaldone; Lukas Ronner; Phyllis A Gimotty; Sarah F Adams
Journal: Cancer Immunol Res Date: 2015-07-02 Impact factor: 11.151

3. Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function.

Authors: Felix Y Feng; Johann S de Bono; Mark A Rubin; Karen E Knudsen
Journal: Mol Cell Date: 2015-06-18 Impact factor: 17.970

4. PARP-1 controls NK cell recruitment to the site of viral infection.

Authors: Qiyang Shou; Huiying Fu; Xiaopei Huang; Yiping Yang
Journal: JCI Insight Date: 2019-06-20

5. Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines.

Authors: Gurjit Singh; Anudeep Kaur; Jashanpreet Kaur; Manpreet S Bhatti; Palwinder Singh; Rajbir Bhatti
Journal: Inflammopharmacology Date: 2019-04-05 Impact factor: 4.473

Role of poly(ADP-ribose) polymerases in the regulation of inflammatory processes.

1. The clinically used PARP inhibitor olaparib improves organ function, suppresses inflammatory responses and accelerates wound healing in a murine model of third-degree burn injury.

2. CTLA-4 Blockade Synergizes Therapeutically with PARP Inhibition in BRCA1-Deficient Ovarian Cancer.

3. Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function.

4. PARP-1 controls NK cell recruitment to the site of viral infection.

5. Bergapten inhibits chemically induced nociceptive behavior and inflammation in mice by decreasing the expression of spinal PARP, iNOS, COX-2 and inflammatory cytokines.

Review 6. Beyond DNA repair, the immunological role of PARP-1 and its siblings.

Review 7. Crosstalk between poly(ADP-ribose) polymerase and sirtuin enzymes.

8. Ferulic acid protects against radiation-induced testicular damage in male rats: impact on SIRT1 and PARP1.

Review 9. The PARP Enzyme Family and the Hallmarks of Cancer Part 2: Hallmarks Related to Cancer Host Interactions.

Review 10. PARP Inhibitors: An Innovative Approach to the Treatment of Inflammation and Metabolic Disorders in Sepsis.