Literature DB >> 2302237

Protein kinase C-gamma is present in adriamycin resistant HL-60 leukemia cells.

A Aquino1, B S Warren, J Omichinski, K D Hartman, R I Glazer.   

Abstract

The isoform pattern of protein kinase C (PKC) was examined in wild-type and Adriamycin-resistant (HL-60/AR) HL-60 leukemia cells. Analyses were carried out by immunoblotting with mouse monoclonal antibodies against PKC-alpha and PKC-beta and a rabbit polyclonal antibody against the variable (V3) region of PKC-gamma. HL-60/AR cells contained an equivalent level of PKC-alpha and a lower amount of PKC-beta than HL-60 cells. In contrast, only HL-60/AR cells contained PKC-gamma. These results indicate that the regulation of this family of isoenzymes is altered in drug-resistant cells.

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Year:  1990        PMID： 2302237     DOI： 10.1016/0006-291x(90)90869-o

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  13 in total

1.  Protein kinases and multidrug resistance.

Authors:  M G Rumsby; L Drew; J R Warr
Journal:  Cytotechnology       Date:  1998-09       Impact factor: 2.058

2.  Inhibition of protein kinase C in multidrug-resistant cells by modulators of multidrug resistance.

Authors:  Y P Hu; J Robert
Journal:  J Cancer Res Clin Oncol       Date:  1997       Impact factor: 4.553

Review 3.  Effects of phosphorylation of P-glycoprotein on multidrug resistance.

Authors:  U A Germann; T C Chambers; S V Ambudkar; I Pastan; M M Gottesman
Journal:  J Bioenerg Biomembr       Date:  1995-02       Impact factor: 2.945

4.  Increased expression and DNA-binding activity of transcription factor Sp1 in doxorubicin-resistant HL-60 leukemia cells.

Authors:  F Borellini; A Aquino; S F Josephs; R I Glazer
Journal:  Mol Cell Biol       Date:  1990-10       Impact factor: 4.272

5.  LysoPCs induce Hck- and PKCδ-mediated activation of PKCγ causing p47phox phosphorylation and membrane translocation in neutrophils.

Authors:  Marguerite R Kelher; Nathan J D McLaughlin; Anirban Banerjee; David J Elzi; Fabia Gamboni; Samina Y Khan; Xianzhong Meng; Sanchayita Mitra; Christopher C Silliman
Journal:  J Leukoc Biol       Date:  2016-08-16       Impact factor: 4.962

6.  Antisense expression of PKCalpha improved sensitivity of SGC7901/VCR cells to doxorubicin.

Authors:  Da-Long Wu; Feng-Ying Sui; Cheng Du; Cheng-Wen Zhang; Bin Hui; Shui-Ling Xu; Huan-Zhang Lu; Guo-Jie Song
Journal:  World J Gastroenterol       Date:  2009-03-14       Impact factor: 5.742

Review 7.  Regulation of protein kinase C and role in cancer biology.

Authors:  G C Blobe; L M Obeid; Y A Hannun
Journal:  Cancer Metastasis Rev       Date:  1994-12       Impact factor: 9.264

Review 8.  Non-P-glycoprotein multidrug resistance in cell lines which are defective in the cellular accumulation of drug.

Authors:  M S Center
Journal:  Cytotechnology       Date:  1993       Impact factor: 2.058

9.  Phorbol ester selectively stimulates the phospholipase D-mediated hydrolysis of phosphatidylethanolamine in multidrug-resistant MCF-7 human breast carcinoma cells.

Authors:  Z Kiss; M Tomono; W B Anderson
Journal:  Biochem J       Date:  1994-09-15       Impact factor: 3.857

10.  Further identification of protein kinase C isozymes in mouse epidermis.

Authors:  X J Wang; B S Warren; L M Beltrán; S P Fosmire; J DiGiovanni
Journal:  J Cancer Res Clin Oncol       Date:  1993       Impact factor: 4.553
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