BACKGROUND: Mammographic density (MD) is regarded as an intermediate phenotype in breast cancer development. This association study investigated the influence of 14 breast cancer susceptibility loci identified through previous genome-wide association studies on MD among the participants in the "Determinants of Density in Mammographies in Spain" (DDM-Spain) study. METHODS: Our study covered a total of 3348 Caucasian women aged 45-68years, recruited from seven Spanish breast cancer screening centres having DNA available. Mammographic density was blindly assessed by a single reader using a semiquantitative scale. Ordinal logistic models, adjusted for age, body mass index and menopausal status, were used to estimate the association between each genotype and MD. RESULTS: Evidence of association with MD was found for variant rs3803662 (TOX3) (Odds Ratio (OR)=1.13, 95% Confidence Interval (CI)=1.03-1.25), and marginal evidence of association for susceptibility loci rs3817198 (LSP1) (OR=1.09, 95% CI=1.00-1.20) and rs2981582 (FGFR2) (OR=0.92, 95% CI=0.84-1.01). Two other loci were associated with MD solely among pre-menopausal women, namely, rs4973768 (SLC4A7) (OR=0.83, 95% CI=0.70-1.00) and rs4415084 (MEPS30) (OR=1.22, 95% CI=1.00-1.49). CONCLUSIONS: Our findings lend some support to the hypothesis which links these susceptibility loci to MD.
BACKGROUND: Mammographic density (MD) is regarded as an intermediate phenotype in breast cancer development. This association study investigated the influence of 14 breast cancer susceptibility loci identified through previous genome-wide association studies on MD among the participants in the "Determinants of Density in Mammographies in Spain" (DDM-Spain) study. METHODS: Our study covered a total of 3348 Caucasian women aged 45-68years, recruited from seven Spanish breast cancer screening centres having DNA available. Mammographic density was blindly assessed by a single reader using a semiquantitative scale. Ordinal logistic models, adjusted for age, body mass index and menopausal status, were used to estimate the association between each genotype and MD. RESULTS: Evidence of association with MD was found for variant rs3803662 (TOX3) (Odds Ratio (OR)=1.13, 95% Confidence Interval (CI)=1.03-1.25), and marginal evidence of association for susceptibility loci rs3817198 (LSP1) (OR=1.09, 95% CI=1.00-1.20) and rs2981582 (FGFR2) (OR=0.92, 95% CI=0.84-1.01). Two other loci were associated with MD solely among pre-menopausal women, namely, rs4973768 (SLC4A7) (OR=0.83, 95% CI=0.70-1.00) and rs4415084 (MEPS30) (OR=1.22, 95% CI=1.00-1.49). CONCLUSIONS: Our findings lend some support to the hypothesis which links these susceptibility loci to MD.
Authors: James L Miller; Arianna P Bartlett; Rebecca M Harman; Prabin Dhangada Majhi; D Joseph Jerry; Gerlinde R Van de Walle Journal: J Mammary Gland Biol Neoplasia Date: 2022-07-29 Impact factor: 2.698
Authors: Myrto Barrdahl; Federico Canzian; Sara Lindström; Irene Shui; Amanda Black; Robert N Hoover; Regina G Ziegler; Julie E Buring; Stephen J Chanock; W Ryan Diver; Susan M Gapstur; Mia M Gaudet; Graham G Giles; Christopher Haiman; Brian E Henderson; Susan Hankinson; David J Hunter; Amit D Joshi; Peter Kraft; I-Min Lee; Loic Le Marchand; Roger L Milne; Melissa C Southey; Walter Willett; Marc Gunter; Salvatore Panico; Malin Sund; Elisabete Weiderpass; María-José Sánchez; Kim Overvad; Laure Dossus; Petra H Peeters; Kay-Tee Khaw; Dimitrios Trichopoulos; Rudolf Kaaks; Daniele Campa Journal: Int J Cancer Date: 2015-08-14 Impact factor: 7.396
Authors: Teresa Ramón Y Cajal; Isabel Chirivella; Josefa Miranda; Alexandre Teule; Ángel Izquierdo; Judith Balmaña; Ana Beatriz Sánchez-Heras; Gemma Llort; David Fisas; Virginia Lope; Elena Hernández-Agudo; María José Juan-Fita; Isabel Tena; Luis Robles; Carmen Guillén-Ponce; Pedro Pérez-Segura; Mari Sol Luque-Molina; Susana Hernando-Polo; Mónica Salinas; Joan Brunet; María Dolores Salas-Trejo; Agustí Barnadas; Marina Pollán Journal: Breast Cancer Res Date: 2015-07-11 Impact factor: 6.466
Authors: Brad M Keller; Anne Marie McCarthy; Jinbo Chen; Katrina Armstrong; Emily F Conant; Susan M Domchek; Despina Kontos Journal: BMC Cancer Date: 2015-03-18 Impact factor: 4.430
Authors: John A Colletti; Kristin M Leland-Wavrin; Scott G Kurz; Maureen Peters Hickman; Nicole L Seiler; Nyssa Becker Samanas; Quincy A Eckert; Kirsten L Dennison; Lina Ding; Beverly S Schaffer; James D Shull Journal: G3 (Bethesda) Date: 2014-05-28 Impact factor: 3.154