Analysis of indications for referral to a multidisciplinary medical genetics clinic: implications for training programs in obstetrics and gynecology.

Clinical genetics has become an integral component of obstetric training. Advances in prenatal screening (particularly maternal serum alpha-fetoprotein) and the clinical applications of molecular technologies have broadened the indications for referral to geneticists. During the study period, 1237 patients were referred for genetics consultation. A total of 596 (48%) were referred because of cytogenetic indications (576 for genetic amniocentesis); 252 (20%) because of multifactorial-developmental abnormalities; 204 (17%) because of risk of diseases attributable to single-gene mutations; 58 (5%) because of antenatal teratogen exposure(s); and 127 (10%) because of other reasons. Herein we summarize our experience as a multidisciplinary genetics unit and offer recommendations for broadening resident training curricula to meet current clinical needs. These data will be useful for enhancement of health care use and more effective direction of limited resources.