BACKGROUND: Reduced hippocampal size and increased stress sensitivity are associated with psychotic disorder and familial risk for psychosis. However, to what degree the hippocampus is implicated in daily life stress reactivity has not yet been examined. The current study investigated (i) whether familial risk (the contrast between controls, patients and siblings of patients) moderated the relationship between hippocampal volume (HV) and emotional daily stress reactivity and (ii) whether familial risk (the contrast between controls and siblings of patients) moderated the relationship between HV and cortisol daily stress reactivity. Method T1-weighted magnetic resonance imaging (MRI) scans were acquired from 20 patients with schizophrenia, 37 healthy siblings with familial risk for schizophrenia and 32 controls. Freesurfer 5.0.0 was used to measure HV. The experience sampling method (ESM), a structured momentary assessment technique, was used to assess emotional stress reactivity, that is the effect of momentary stress on momentary negative affect (NA). In addition, in the control and sibling groups, cortisol stress reactivity was assessed using momentary cortisol levels extracted from saliva. RESULTS: Multilevel linear regression analyses revealed a significant three-way interaction between group, HV and momentary stress in both the model of NA and the model of cortisol. Increased emotional stress reactivity was associated with smaller left HV in patients and larger total HV in controls. In line with the results in patients, siblings with small HV demonstrated increased emotional and cortisol stress reactivity compared to those with large HV. CONCLUSIONS: HV may index risk and possibly disease-related mechanisms underlying daily life stress reactivity in psychotic disorder.
BACKGROUND: Reduced hippocampal size and increased stress sensitivity are associated with psychotic disorder and familial risk for psychosis. However, to what degree the hippocampus is implicated in daily life stress reactivity has not yet been examined. The current study investigated (i) whether familial risk (the contrast between controls, patients and siblings of patients) moderated the relationship between hippocampal volume (HV) and emotional daily stress reactivity and (ii) whether familial risk (the contrast between controls and siblings of patients) moderated the relationship between HV and cortisol daily stress reactivity. Method T1-weighted magnetic resonance imaging (MRI) scans were acquired from 20 patients with schizophrenia, 37 healthy siblings with familial risk for schizophrenia and 32 controls. Freesurfer 5.0.0 was used to measure HV. The experience sampling method (ESM), a structured momentary assessment technique, was used to assess emotional stress reactivity, that is the effect of momentary stress on momentary negative affect (NA). In addition, in the control and sibling groups, cortisol stress reactivity was assessed using momentary cortisol levels extracted from saliva. RESULTS: Multilevel linear regression analyses revealed a significant three-way interaction between group, HV and momentary stress in both the model of NA and the model of cortisol. Increased emotional stress reactivity was associated with smaller left HV in patients and larger total HV in controls. In line with the results in patients, siblings with small HV demonstrated increased emotional and cortisol stress reactivity compared to those with large HV. CONCLUSIONS: HV may index risk and possibly disease-related mechanisms underlying daily life stress reactivity in psychotic disorder.
Authors: Tyler B Grove; Ivy F Tso; Jinsoo Chun; Savanna A Mueller; Stephan F Taylor; Vicki L Ellingrod; Melvin G McInnis; Patricia J Deldin Journal: Psychiatry Res Date: 2016-06-25 Impact factor: 3.222
Authors: R Blakey; S Ranlund; E Zartaloudi; W Cahn; S Calafato; M Colizzi; B Crespo-Facorro; C Daniel; Á Díez-Revuelta; M Di Forti; C Iyegbe; A Jablensky; R Jones; M-H Hall; R Kahn; L Kalaydjieva; E Kravariti; K Lin; C McDonald; A M McIntosh; M Picchioni; J Powell; A Presman; D Rujescu; K Schulze; M Shaikh; J H Thygesen; T Toulopoulou; N Van Haren; J Van Os; M Walshe; R M Murray; E Bramon Journal: Psychol Med Date: 2017-11-02 Impact factor: 7.723
Authors: R Magalhães; J Bourgin; F Boumezbeur; P Marques; M Bottlaender; C Poupon; B Djemaï; E Duchesnay; S Mériaux; N Sousa; T M Jay; A Cachia Journal: Transl Psychiatry Date: 2017-01-24 Impact factor: 6.222
Authors: Siri Ranlund; Stella Calafato; Johan H Thygesen; Kuang Lin; Wiepke Cahn; Benedicto Crespo-Facorro; Sonja M C de Zwarte; Álvaro Díez; Marta Di Forti; Conrad Iyegbe; Assen Jablensky; Rebecca Jones; Mei-Hua Hall; Rene Kahn; Luba Kalaydjieva; Eugenia Kravariti; Colm McDonald; Andrew M McIntosh; Andrew McQuillin; Marco Picchioni; Diana P Prata; Dan Rujescu; Katja Schulze; Madiha Shaikh; Timothea Toulopoulou; Neeltje van Haren; Jim van Os; Evangelos Vassos; Muriel Walshe; Cathryn Lewis; Robin M Murray; John Powell; Elvira Bramon Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2017-08-29 Impact factor: 3.568