Literature DB >> 23013356

Elaiomycins D-F, antimicrobial and cytotoxic azoxides from Streptomyces sp. strain HKI0708.

Ling Ding1, Basile Le Sage Tchize Ndejouong, Armin Maier, Heinz-Herbert Fiebig, Christian Hertweck.   

Abstract

Five new congeners of elaiomycin featuring the rare azoxy function were isolated from Streptomyces sp. strain HKI0708. Individual elaiomycins exhibit specific antimycobacterial, anti-Aspergillus, and cytotoxic activities, providing provisional data on structure-activity relationships. The co-occurrence of the azoxide variants indicates a biogenetic relationship that illustrates new diversification steps in elaiomycin biosynthesis.

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Year:  2012        PMID： 23013356     DOI： 10.1021/np300329m

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  8 in total

Review 1.  Heteroatom-Heteroatom Bond Formation in Natural Product Biosynthesis.

Authors:  Abraham J Waldman; Tai L Ng; Peng Wang; Emily P Balskus
Journal:  Chem Rev       Date:  2017-04-04       Impact factor: 60.622

2.  Ontogenetic Changes in Azoxyglycoside Levels in the Leaves of Dioon edule Lindl.

Authors:  Alberto Prado; Gabriel Rubio-Mendez; Laura Yañez-Espinosa; Jacqueline C Bede
Journal:  J Chem Ecol       Date:  2016-10-04       Impact factor: 2.626

3.  Pharmacological and Predicted Activities of Natural Azo Compounds.

Authors:  Valery M Dembitsky; Tatyana A Gloriozova; Vladimir V Poroikov
Journal:  Nat Prod Bioprospect       Date:  2017-01-04

4.  Molecular mechanism of azoxy bond formation for azoxymycins biosynthesis.

Authors:  Yuan-Yang Guo; Zhen-Hua Li; Tian-Yu Xia; Yi-Ling Du; Xu-Ming Mao; Yong-Quan Li
Journal:  Nat Commun       Date:  2019-10-08       Impact factor: 14.919

5.  Anti-cancer and antimicrobial potential of five soil Streptomycetes: a metabolomics-based study.

Authors:  Nada Osama; Walid Bakeer; Mai Raslan; Hanan A Soliman; Usama Ramadan Abdelmohsen; Mohamed Sebak
Journal:  R Soc Open Sci       Date:  2022-02-09       Impact factor: 2.963

6.  New azodyrecins identified by a genome mining-directed reactivity-based screening.

Authors:  Atina Rizkiya Choirunnisa; Kuga Arima; Yo Abe; Noritaka Kagaya; Kei Kudo; Hikaru Suenaga; Junko Hashimoto; Manabu Fujie; Noriyuki Satoh; Kazuo Shin-Ya; Kenichi Matsuda; Toshiyuki Wakimoto
Journal:  Beilstein J Org Chem       Date:  2022-08-10       Impact factor: 2.544

Review 7.  Natural Products from Actinobacteria as a Potential Source of New Therapies Against Colorectal Cancer: A Review.

Authors:  Yadollah Bahrami; Sasan Bouk; Elham Kakaei; Mohammad Taheri
Journal:  Front Pharmacol       Date:  2022-07-11       Impact factor: 5.988

8.  Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV-2 Viruses.

Authors:  Shun Saito; Kayo Funayama; Wataru Kato; Mayu Okuda; Meiko Kawamoto; Teruhiko Matsubara; Toshinori Sato; Akihiko Sato; Satoko Otsuguro; Michihito Sasaki; Yasuko Orba; Hirofumi Sawa; Katsumi Maenaka; Kazutoshi Shindo; Masaya Imoto; Midori A Arai
Journal:  J Nat Prod       Date:  2022-10-12       Impact factor: 4.803
  8 in total

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